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di·eth·yl·stil·bes·trol (DES),(dī-eth'il-stil-bes'trol), Avoid the misspelling/mispronunciation diethylstilbesterol.
A synthetic nonsteroidal estrogenic compound. Sometimes used as a postcoital antipregnancy agent to prevent implantation of the fertilized ovum. The first demonstrated transplacental carcinogen responsible for a delayed clear cell vaginal carcinoma in female offspring of mothers who took the drug during pregnancy when the drug was erroneously thought to prevent threatened abortion.
a synthetic estrogen used in the treatment of female animals for infertility and bitches for urinary incontinence. Its use as a growth promotant, especially in cattle, has been discontinued because of fears that it is a carcinogen. Its use is also not without toxicity hazards.
Overfeeding of stilbestrol as a growth promotant causes poisoning characterized by relaxation of pelvic ligaments, elevation of the tailhead, susceptibility to pelvic fracture and hip dislocation and prolapse of rectum and vagina. In castrated males there is a tendency for obstructive urolithiasis to occur. Pigs also show anuria, kidney enlargement and thickening of the ureters.