stilbestrol


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di·eth·yl·stil·bes·trol (DES),

(dī-eth'il-stil-bes'trol), Avoid the misspelling/mispronunciation diethylstilbesterol.
A synthetic nonsteroidal estrogenic compound. Sometimes used as a postcoital antipregnancy agent to prevent implantation of the fertilized ovum. The first demonstrated transplacental carcinogen responsible for a delayed clear cell vaginal carcinoma in female offspring of mothers who took the drug during pregnancy when the drug was erroneously thought to prevent threatened abortion.
Synonym(s): stilbestrol

stilbestrol

(stĭl-bĕs′trôl′, -trōl′)
n.
DES.

stilbestrol

stilbestrol

a synthetic estrogen used in the treatment of female animals for infertility and bitches for urinary incontinence. Its use as a growth promotant, especially in cattle, has been discontinued because of fears that it is a carcinogen. Its use is also not without toxicity hazards.
Overfeeding of stilbestrol as a growth promotant causes poisoning characterized by relaxation of pelvic ligaments, elevation of the tailhead, susceptibility to pelvic fracture and hip dislocation and prolapse of rectum and vagina. In castrated males there is a tendency for obstructive urolithiasis to occur. Pigs also show anuria, kidney enlargement and thickening of the ureters.
References in periodicals archive ?
In the OVX animals, the uterus weight of mice treated with stilbestrol was highly significantly heavier than those of vehicle- and formononetin-treated mice (p<0.
Occasionally [sic] a nauseated patient became worse on stilbestrol, but usually there was no relationship between the two.
In the second questionnaire, experts were asked whether they had any "comments or theories" about the "possible mechanism by which Stilbestrol produce[d] nausea.
Palestrol Restrol Stil-Rol Stilbal Stilbestrol Stilbestronate Stilbetin Stilbinol Stilboestroform Stilboestrol Stilboestrol DP.
The effects of stilbestrol, testosterone, and thyroid alterations on growth and fattening of beef heifers.
In fact, DES is a stilbestrol derivative whose core structure is that of the plant product stilbene, of which 4-OH-stilbene was also found to be an active disruptor of ER and NodD signaling.
Effects of estradiol, stilbestrol, and some alkyl-carbonyl androstanes upon sex differentiation in the medaka, Oryzias latipes.
Association of the maternal stilbestrol therapy with tumor appearance in young women.