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Due to its importance of tropical infectious disease, the discovery of new drugs against it are in progress [30,31] Drugs normally used include pentamidine, glucantine, bis-amidines, antimonial, and stilbamidine show high toxicities, grow clinical resistance and presently contribute to increase co-infections leishmaniasis-AIDS [32-33].
These drugs include neomycin sulfate, paromomycin, natamycin, ketoconazole, ciclopirox olamine, [23] pentamidine isethionate, propamidine isethionate, stilbamidine isethionate, [24] amphotericin B, sulfadiazine, sulfisoxazole, sulfamethoxazole, polymyxin B and E, [25] and clotrimazole.