stiff-person syndrome

(stĭf′pûr′sən)

An adult-onset neurological disorder characterized by muscle spasms and progressive muscle stiffness.

stiff-per·son syn·drome

(stif'pĕr-sŏn sin'drōm)

A rare disorder manifested clinically by the continuous isometric contraction of many of the somatic muscles; contractions are usually forceful and painful and most frequently involve the trunk musculature, although limb muscles may be involved. This is an autoimmune disease, with circulating antibodies against the GABA-synthesizing enzyme and glutamic acid decarboxylase, among other types of antibodies present.

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References in periodicals archive ?

Stiff-Person Syndrome afflicts twice as many women as men and is often misdiagnosed as a range of conditions, including Parkinson's disease and multiple sclerosis.

A prisoner in my own home; mum whose illness causes her to swell up 'like the hulk' hits out as funding is axed

The clinical spectrum of anti- GAD antibody-positive patients with stiff-person syndrome.

Stiff person syndrome with pyramidal signs

Progress and stiff challenges in understanding the role of GAD-antibodies in stiff-person syndrome.

A stiff person case admitted phsysical medicine and rehabilitation outpatient clinic with low back pain/Bel agrisi sikayetiyle fiziksel tip ve rehabilitasyon poliklinigine basvuran bir stiff person sendromu olgusu

They discuss the pretherapeutic history of botulinum neurotoxin, the history of its clinical development, its pharmacology and immunological properties, and treatments for cervical dystonia, blepharospasm, oromandibular dystonia, laryngeal muscle hyperactivity syndromes, otorhinolaryngological conditions, hemifacial spasm, spasticity, spastic infantile cerebral palsy, tic disorders, essential hand and head tremor, stiff-person syndrome, ophthalmological applications, cosmetic uses, hyperhidrosis, ischemic digits, neuropathic pain, headaches, musculoskeletal pain and arthritis, plantar fasciitis, low-back pain, piriformis syndrome, the gastrointestinal tract, and urological disorders.

Manual of Botulinum Toxin Therapy, 2nd Edition

org STIFF-PERSON SYNDROME Stiff-person syndrome is a rare neurological disorder with features of an autoimmune disease.

Forever smelling the roses; Mother-of-three Jacqui Atkinson has spent the past 20 years living - and nearly dying - with the one-in-a-million condition, Stiff Person Syndrome. Now she has chronicled her struggles and victories in a book she hopes will help fellow sufferers. SAM WONFOR talks to her

Rigidity and spasms from autoimmune encephalomyopathies: Stiff-person syndrome.

Stiff person syndrome (SPS): literature review and case report

Her one-in-a-million disorder - called stiff-person syndrome - leaves her body frozen and an attack could be fatal.

I AM THE HULK; Rare condition makes muscles swell 5st in 5 hours

The glutamic acid decarboxylase antibody test for stiff-person syndrome was negative, as were serologic tests for Lyme disease, WNV, and syphilis.

Human rabies--Wisconsin, 2010

Rakocevic G, Raju R, Dalakas MC Anti-glutamic acid decarboxylase antibodies in the serum and cerebrospinal fluid of patients with stiff-person syndrome.

Study finds link between GMOs and current health care crisis

CHICAGO -- Intravenous immunoglobulin was safe and effective for treating certain patients with stiff-person syndrome, Dr.

IVIG Cuts Stiff-Person Symptoms In Anti-GAD--Positive Patients. (Small Double-Blind Study)

Helen Stephens, aged 50, from Wednesbury, was originally told by doctors she had Stiff-Person Syndrome (SPS) - which means her muscles tear and expand making her swell by four inches.