stiff-person syndrome

(stĭf′pûr′sən)

An adult-onset neurological disorder characterized by muscle spasms and progressive muscle stiffness.

stiff-per·son syn·drome

(stif'pĕr-sŏn sin'drōm)

A rare disorder manifested clinically by the continuous isometric contraction of many of the somatic muscles; contractions are usually forceful and painful and most frequently involve the trunk musculature, although limb muscles may be involved. This is an autoimmune disease, with circulating antibodies against the GABA-synthesizing enzyme and glutamic acid decarboxylase, among other types of antibodies present.

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References in periodicals archive ?

Bedridden woman with 'stiff-person syndrome' is refused treatment for "not fully proven" illness on the NHS

Brave girl, 9, who once tried to steal Kate Middleton's flowers dies "beautiful" death in her parents' arms; Little Mia Murchison died 10 days ago after courageously battling a rare, genetic disease that robbed her of the ability to walk, talk, see or eat

We had nine patients with PNS; two patients had subacute cerebellar degeneration (SCD); three had Stiff-person syndrome (SPS); one had Lambert-Eaton myasthenic syndrome (LEMS); and the remaining patient had sensory neuropathy (SN).

Paraneoplastic Neurologic Syndromes: Rare But More Common Than Expected Nine Cases with a Literature Review/Paraneoplastik Norolojik Sendromlar: Nadir Ancak Beklenenden Daha Sik Dokuz Olgu ile Literatur Derlemesi

Mackay, "Stiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: protean additions to the autoimmune central neuropathies," Journal of Autoimmunity, vol.

Difficult to Treat Focal, Stiff Person Syndrome of the Left Upper Extremity

I'm like a bodybuilder." Stiff-Person Syndrome afflicts twice as many women as men and is often misdiagnosed as a range of conditions, including Parkinson's disease and multiple sclerosis.

A prisoner in my own home; mum whose illness causes her to swell up 'like the hulk' hits out as funding is axed

The clinical spectrum of anti- GAD antibody-positive patients with stiff-person syndrome. Neurology 2000; 55:1531-1535.

Stiff person syndrome with pyramidal signs

Progress and stiff challenges in understanding the role of GAD-antibodies in stiff-person syndrome. Exp Neurol 2013;247:303-7.

A stiff person case admitted phsysical medicine and rehabilitation outpatient clinic with low back pain/Bel agrisi sikayetiyle fiziksel tip ve rehabilitasyon poliklinigine basvuran bir stiff person sendromu olgusu

Stiff-person syndrome associated with oral isotretinoin treatment.

A case with bilateral sacroiliitis and polyneuropathy development due to isotretinoin use

They discuss the pretherapeutic history of botulinum neurotoxin, the history of its clinical development, its pharmacology and immunological properties, and treatments for cervical dystonia, blepharospasm, oromandibular dystonia, laryngeal muscle hyperactivity syndromes, otorhinolaryngological conditions, hemifacial spasm, spasticity, spastic infantile cerebral palsy, tic disorders, essential hand and head tremor, stiff-person syndrome, ophthalmological applications, cosmetic uses, hyperhidrosis, ischemic digits, neuropathic pain, headaches, musculoskeletal pain and arthritis, plantar fasciitis, low-back pain, piriformis syndrome, the gastrointestinal tract, and urological disorders.

Manual of Botulinum Toxin Therapy, 2nd Edition

To find out more about St Oswald's, visit www.stoswaldsuk.org STIFF-PERSON SYNDROME Stiff-person syndrome is a rare neurological disorder with features of an autoimmune disease.

Forever smelling the roses; Mother-of-three Jacqui Atkinson has spent the past 20 years living - and nearly dying - with the one-in-a-million condition, Stiff Person Syndrome. Now she has chronicled her struggles and victories in a book she hopes will help fellow sufferers. SAM WONFOR talks to her

The stiff-person syndrome: An autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid.

Stiff person syndrome (SPS): literature review and case report

Central nervous system Limbic encephalitis Encephalomyelitis Brainstem encephalitis Stiff-person syndrome Opsoclonus-myoclonus Subacute cerebellar degeneration Paraneoplastic visual syndromes Cancer-associated retinopathy Melanoma-associated retinopathy Paraneoplastic optic neuropathy Motor neuron syndromes Subacute motor neuronopathy Other motor neuron syndromes Peripheral nervous system Acute sensorimotor neuropathy Subacute sensory neuronopathy Chronic sensorimotor neuropathy Subacute autonomic neuropathy Paraneoplastic peripheral nerve vasculitis Neuromuscular junction and muscle Myasthenia gravis Lambert-Eaton syndrome Polymyositis/dermatomyositis Acute necrotizing myopathy Cachectic myopathy Neuromyotonia TABLE 2: Diagnostic criteria of paraneoplastic limbic encephalitis.

Are onconeural antibodies a clinical phenomenology in paraneoplastic limbic encephalitis?

Her one-in-a-million disorder - called stiff-person syndrome - leaves her body frozen and an attack could be fatal.