SREBF1

(redirected from sterol regulatory element-binding protein 1)

SREBF1

A gene on chromosome 17p11.2 that encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor, which binds to the sterol regulatory element-1 (SRE1), a decamer flanking the low-density lipoprotein receptor gene and genes involved in sterol biosynthesis. The protein is synthesised as a precursor attached to the nuclear membrane and endoplasmic reticulum; once cleaved, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit precursor cleavage; the mature nuclear form is rapidly catabolised, reducing transcription.
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ChREBP as a determinant transcriptional factor, forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, regulated lipid synthesis in liver at the transcriptional level by binding to conservative sequences carbohydrate response element (ChoRE) in promoter of glycolysis and triglyceride synthesis genes, including fatty acid synthase (FAS), sterol regulatory element-binding protein 1 (SREBP1), acetyl CoA carboxylase (ACC) and L-type pyruvate kinase (L-PK) (Ma et al., 2006; Liu et al., 2018).
Fish oil feeding decreases mature sterol regulatory element-binding protein 1 by down-regulation of SREBP-1c mRNA in mouse liver.

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