Previous phytochemical investigation of the extracts of Solanum surattense revealed the presence of steroids, terpenes, phenolics, saponins, fatty acids, alkaloids , steroidal alkaloids and steroidal saponins
, specifically protodioscin, present in these plants may be responsible for liver injury (CASTRO et al., 2011).
is another class of chemical constituents present in S.
Fraction D was subjected to chromatography using a preparative HPLC column, whereby five steroidal saponins
, compounds 1a/b, 2-5, were isolated (Figs.
Sethi, "Diosgenin, a steroidal saponin
, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells," Cancer Letters, vol.
ASC, a bioactive steroidal saponin
from Ophitopogin japonicas, inhibits angiogenesis through interruption of Src tyrosine kinase-dependent matrix metalloproteinase pathway.
This is consistent with our earlier research in that the steroidal saponins
(the effective compound of this surfactant), promoted growth of ruminal bacteria that digest starch, enhanced in vitro digestion of barley grain, increased microbial protein synthesis and the ratio of propionic to acetic acid, decreased protozoal numbers and reduced protein degradation in the rumen (Wang et al., 1998, 2000a, b).
Antitumour and immunomodulating activities of diosgenin, a naturally occurring steroidal saponin
. Natural Product Research 26,2243-2246.
In this study, we investigated effect of steroidal saponin
of Trillium Tschonoskii (TTS) on MDR HCC.
In this study, the cytotoxicity of some phytochemicals, including phenolics (EGCG and thymol), terpenoids (menthol, aromadendrene, [beta]-sitosterol-O-glucoside, and [beta]-carotene) and alkaloids (glaucine, harmine, and sanguinarine) were investigated alone or in combination with the cytotoxic monodesmo-sidic steroidal saponin
digitonin in Caco-2, MCF-7, CEM/ADR5000, and CCRF-CEM cells.
1996), and steroidal saponin
as aculeatiside A and B (Saijo et al.