NCOA1

(redirected from steroid receptor coactivator-1)

NCOA1

A gene on chromosome 2p23 that encodes a protein of the p160/steroid receptor coactivator family, which acts as a transcriptional coactivator for steroid and nuclear hormone receptors, coactivating different nuclear receptors—e.g., PGR, GR and ER, retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors, and may participate in chromatin remodelling and recruitment of general transcription factors. NCOA1 acts with NCOA2 to control energy balance between white and brown adipose tissues.
References in periodicals archive ?
Both RIF and BPA strongly promoted the specific interaction of steroid receptor coactivator-1 (SRC1) and peroxisome proliferator-activated receptor-binding protein (PBP) in a dose- dependent manner (Figure IE).
First, we assayed chemicals to determine their ability to modulate direct interaction between the hER[Alpha] and the steroid receptor coactivator-1 (SRC-1) and in a competition binding assay to displace 17[Beta]-estradiol ([E.
This assay is based on the direct ligand-dependent interaction between the ER and the transcriptional steroid receptor coactivator-1 (SRC-1) after activation of the receptor, which results from a ligand-induced conformational change.
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