Steroid 5a-reductase | definition of steroid 5a-reductase by Medical dictionary
steroid 5alpha-reductase (redirected from steroid 5a-reductase)
an enzyme that uses NADPH to reduce certain steroids (for example, the conversion of testosterone to dihydrotestosterone); a deficiency of this enzyme is associated with a form of male pseudohermaphroditism in which genetic males have male genitals as well as female external genitalia.
References in periodicals archive
Wilson et al., Steroid 5a-Reductase
2 Deficiency, 14 endocrine Rev.
The patent offers once-weekly oral administration of selective inhibitors of type 1 and/or type 2 isoforms of steroid 5a-reductase
, to patients with nodulocystic and conglobate acne vulgaris.
The biologically active androgen dihydrotestosterone is produced from testosterone in the prostate by the action of type 1 and type 2 steroid 5a-reductase