steroid 5alpha-reductase

(redirected from steroid 5a-reductase)

ster·oid 5α-re·duc·tase

an enzyme that uses NADPH to reduce certain steroids (for example, the conversion of testosterone to dihydrotestosterone); a deficiency of this enzyme is associated with a form of male pseudohermaphroditism in which genetic males have male genitals as well as female external genitalia.
References in periodicals archive ?
The patent offers once-weekly oral administration of selective inhibitors of type 1 and/or type 2 isoforms of steroid 5a-reductase, to patients with nodulocystic and conglobate acne vulgaris.
The biologically active androgen dihydrotestosterone is produced from testosterone in the prostate by the action of type 1 and type 2 steroid 5a-reductase isoenzymes.
PROSCAR(a) (finasteride), a synthetic 4-azasteroid compound, is a specific inhibitor of steroid 5a-reductase, an intracellular enzyme that converts testosterone into the potent androgen 5a-dihydrotestosterone (DHT).