Steroid 5a-reductase | definition of steroid 5a-reductase by Medical dictionary
steroid 5alpha-reductase (redirected from steroid 5a-reductase)
an enzyme that uses NADPH to reduce certain steroids (for example, the conversion of testosterone to dihydrotestosterone); a deficiency of this enzyme is associated with a form of male pseudohermaphroditism in which genetic males have male genitals as well as female external genitalia.
References in periodicals archive
The biologically active androgen dihydrotestosterone is produced from testosterone in the prostate by the action of type 1 and type 2 steroid 5a-reductase
PROSCAR(a) (finasteride), a synthetic 4-azasteroid compound, is a specific inhibitor of steroid 5a-reductase
, an intracellular enzyme that converts testosterone into the potent androgen 5a-dihydrotestosterone (DHT).