It can be stated that at pH 4, the positive charge of the PSDA block adheres to the carbonate groups on the smooth faces of the crystal lattice, and the PEG block sterically
hinders the classical crystallization of the ionic species, thus resulting in a loose superstructures (Fig.
(f) Cas9 acts as a repressor by sterically
blocking the transcription machinery.
A strategy to overcome these challenges is to attach polyethylene glycol (PEG) to their surface [9,10] in order to form a thin hydrated barrier that sterically
prevents the opsonization process .
However, the benzene ring of indoles or isatins bearing sterically
demanding groups, such as -Br and -N[O.sub.2], could only give corresponding products with lower yields, respectively (Table 2, entries (9), (10), and (14)).
This T790M mutation resulted in conformational change, sterically
hindering erlotinib from binding to the adenosine triphosphate kinase pocket.
There are 2 conformational forms of phytic acid, 5ax/1eq and 1ax/5eq, with the latter being the sterically
favorable form containing 1 axial phosphate and 5 equatorial phosphates.
While the possibility of regioisomers coeluting with 6 in the peak at 6.4 min must not be ruled out, the structure of 6 as the purified product can be rather safely inferred as the result of preferential attack at the sterically
less hindered amino group of 10.
The HMW-PE used in this study is a high-density Lupolen 5261 Z from Lyondell Basell and contains the sterically
hindered primary phenolic antioxidant Irganox 1076 according to the material data sheet.
It is thought that the nine-amino-acid splice insert at site B in NLGN1(+B) sterically
blocks the interaction between NLGN1 and the sixth LNS domain of neurexin 1[alpha] (L6) (refer back to Figure 1) thereby forming a key component of the "neurexin-neuroligin splice code, " reviewed in .
Since the boronic acid unit is sterically
bulkier than acrylamide unit, the conformational flexibility of the polymer chain should be relatively restricted due to the steric hindrance between neighboring boronic acid moieties.
However, this is sufficient for them to "shield" the binding sites of hIFN[gamma] and to hinder sterically
the proper contact between hIFN[gamma] and its receptor.
In this paper, the ultrasonic 3D high- frequency and frequency-conversing volumetric probe were used, and the study found that: this technology could not only retain the advantages of 2D imaging, but also sterically
display the outline of LSC, as well as the relationships of surrounding blood supply and tissues, and measure the anatomical imaging data of lacrimal sac and angular artery.