steric hindrance


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ster·ic hin·drance

interference with or inhibition of a seemingly feasible reaction (usually synthetic) because the size of one or another reactant prevents approach to the required interatomic distance.
References in periodicals archive ?
A primary finding of the molecular simulation results is that the steric hindrance and neighboring molecule effects of reactive moieties on monomers can cause heats of reaction to change up to 17% for urethane-forming reactions.
Terminal, or pendant double bonds (vinyl), have low steric hindrance and are more likely to participate in addition reaction than internal double bonds (cis/trans).
With current two dimensional microarray technology, the restricted density of the probe reactive groups due to steric hindrance and the surface non-uniformity on the slide surface limit assay performance.
In effect, yeast has evolved a platform for protein-protein binding without steric hindrance from cell wall components.
For example, you can introduce a new amino acid that's slightly bigger, causing a steric hindrance [blockage].
Optionally, pegylated phospholipids will be utilized to provide steric hindrance that will further increase residence time and therapeutic efficacy as is done with Doxil([R]), liposome encapsulated doxorubicin.
We first grouped mismatches by type of aromatic ring in the base to assess whether steric hindrance played a role in impeding qPCR amplification.
3] and less reactive Si-OH group might contribute to the decrease in the reaction rate of HMDS due to the steric hindrance.
Vinyl unsaturation is more reactive than in-chain double bonds due to reduced steric hindrance (ref.
This observation was likely related to steric hindrance that led to less accessibility of PCR products to the probe sequences on the array.
We attribute the selectivity to a combination of steric hindrance for complexing molecules larger than benzene and lack of optimal [pi]-[pi] interactions for smaller (non aromatic) molecules.