It can be imaged that the large anions would impose remarkable steric hindrance
on the iron centers.
From a steric hindrance
perspective, varying degrees of reactivity were anticipated and envisioned to follow the reactivity of the olefin on the POSS cage.
The T790M mutation leads to drug resistance by decreasing the binding of TKIs through steric hindrance
and increasing EGFR's binding affinity for adenosine triphosphate.
Remarkably, resulting from its increased donor property and smaller steric hindrance
between the thiophene and BPI unit (vide infra), the thienyl-containing dye (BPI-T) shows an apparent broadening especially for longer wavelength when compared to the phenylene-containing dye (BPI-P).
The adsorption of [H.sup.+] makes the micelles with positive charges and produces the electrostatic repulsion by the polar groups of the CTBA barrier and steric hindrance
. On the other hand, CTAB has a large molecular size as a commonly used cationic surfactant.
Really long probes also don't work well; they have increased likelihood of binding to partial matches, and they can start to have physical steric hindrance
or homodimer interactions, such as hairpin formation, that make them poorly available to interact with sample in the liquid phase.
Though the secondary amine can react with additional epoxide rings, as a result of steric hindrance
and mixing constraints, residual hydrophilic amines (both primary and secondary) will be present in the film.
Finally, the 1,4 isomer has little steric hindrance
or attractive forces affecting the rotation of the N[O.sub.2] groups.
High molecular weight and bulky molecules contributed to steric hindrance
, thus preventing 2a-d from reaching the active site of enzyme .
Since both valine and phenylalanine are hydrophobic amino acids, these unfavorable interactions may cause a steric hindrance
effect in the C2 domain, which may affect its stability or conformation and potentially its interaction with von Willebrand Factor (VWF) and/or phospholipids.
Scientists at the University of Kentucky tested their hypothesis that steric hindrance
and interfacial myofibrillar proteins, when compared with the continuous phase, can more effectively protect oil droplets against oxidative changes.
The structure activity relationship (SAR) study demonstrated that complexation, steric hindrance
, position of substituents, electron density around metal centre, hydrogen bonding and coordination mode of complexed ligands play prime role in modulating the biological activities of complexes.