A primary finding of the molecular simulation results is that the steric hindrance
and neighboring molecule effects of reactive moieties on monomers can cause heats of reaction to change up to 17% for urethane-forming reactions.
Terminal, or pendant double bonds (vinyl), have low steric hindrance
and are more likely to participate in addition reaction than internal double bonds (cis/trans).
With current two dimensional microarray technology, the restricted density of the probe reactive groups due to steric hindrance
and the surface non-uniformity on the slide surface limit assay performance.
In effect, yeast has evolved a platform for protein-protein binding without steric hindrance
from cell wall components.
For example, you can introduce a new amino acid that's slightly bigger, causing a steric hindrance
Optionally, pegylated phospholipids will be utilized to provide steric hindrance
that will further increase residence time and therapeutic efficacy as is done with Doxil([R]), liposome encapsulated doxorubicin.
This dense structure makes the effect of steric hindrance
act on the Cr (VI) removal.
We first grouped mismatches by type of aromatic ring in the base to assess whether steric hindrance
played a role in impeding qPCR amplification.
3] and less reactive Si-OH group might contribute to the decrease in the reaction rate of HMDS due to the steric hindrance
Vinyl unsaturation is more reactive than in-chain double bonds due to reduced steric hindrance
This observation was likely related to steric hindrance
that led to less accessibility of PCR products to the probe sequences on the array.
We attribute the selectivity to a combination of steric hindrance
for complexing molecules larger than benzene and lack of optimal [pi]-[pi] interactions for smaller (non aromatic) molecules.