step-down therapy

step-down therapy

A staged reduction in the dosing and agents used to manage hypertension; the “steps” begin with thiazide diuretics, beta-blockers or ACE inhibitors for patients with mild hypertension (diastolic BP < 100-mm Hg), to hydralazine, prazosine, minoxidil, guanethidine or furosemide for severe hypertension (diastolic BP > 120-mm Hg).

step-down therapy

Cardiology A staged reduction in the doses and agents used to manage HTN; the 'steps' begin with thiazide diuretics, β blockers or ACE inhibitors for Pts with mild HTN, diastolic BP < 100 mm Hg, to hydralazine, prazosine, minoxidil, guanethidine or furosemide for severe HTN, diastolic BP > 120 mm Hg. Cf 'Staircase' ventilation.
References in periodicals archive ?
Oral OCR-002 is a validated ammonia scavenger in development for use as a step-down therapy and for chronic use to maintain remission of hepatic encephalopathy (HE), a neurocognitive disorder associated with serious liver disease.
The availability of both intravenous and oral formulations of solithromycin would enable physicians to step-down therapy from IV to oral administration with the same antibiotic.
Compared with continued combination therapy, LABA step-down therapy was associated with an average 0.
Major Finding: Compared with combination long-acting beta-agonist and inhaled corticosteroid therapy for controlled refractory asthma, LABA step-down therapy was associated with an average 0.
For patients with well-controlled asthma who are on a daily controller medication, half of the respondents endorsed the recommended evaluation at 3-6 months for consideration of step-down therapy.
For most patients with chronic heartburn and regurgitation, step-down therapy to the lowest effective dose of proton pump inhibitors (PPIs) or treatment with a histamine-2 receptor antagonist (H2RA) is a reasonable, cost-effective approach.
Even as we focus our efforts on late-stage clinical development of eravacycline, including the clinical program for a potential oral step-down therapy, we are also advancing other promising compounds from our pipeline of novel tetracyclines to address multidrug-resistant pathogens and difficult-to-treat infections.
SAN DIEGO -- Once-a-day step-down therapy can be an option for patients with mild, persistent asthma that has been stabilized by an inhaled corticosteroid, according to preliminary results from a 500-patient clinical trial presented at the international conference of the American Thoracic Society.
The uptake of tedizolid will be due to its activity against gram-positive pathogens including MRSA, its reduced toxicity compared with Zyvox and its availability as a step-down therapy.
Given that only half of the patients actually received the intervention, an on-treatment analysis would be helpful in determining whether or not step-down therapy would result in deterioration of asthma control, though this type of analysis was not performed.
Step-down therapy allows patients rapid symptom relief and physicians minimal use of medical resources over the course of treatment.