stem cell rescue

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stem cell rescue

In patients being treated with high doses of chemotherapy or radiation therapy, the removal of stem cells (the precursors to red and white blood cells and platelets) from the patient's blood before treatment and their reinfusion after treatment. Granulocyte colony stimulating factor, erythropoietin, and other growth factors are administered to stimulate proliferation of the stem cells after reinfusion. Until adequate numbers of cells repopulate the patient's marrow and bloodstream, the patient is at high risk for infection and bleeding.

Stem cell rescue is used in patients with solid tumors not involving bone marrow who require treatments that would destroy the blood-forming (hematopoietic) cells. The process is immunologically advantageous because the cells infused are the patient's own cells, and thus do not have foreign antigens.

See also: rescue
References in periodicals archive ?
Shakhnovits et al., "High-dose therapy with hematopoietic stem cell rescue in patients with poor prognosis Ewing family tumors," Bone Marrow Transplantation, vol.
These patients will then be further divided in those who either are or are not candidates for high-dose chemotherapy, followed by stem cell rescue.
Maloney's study so far received melphalan 200 mg/[m.sup.2] followed by autologous hematopoietic stem cell rescue. After 40-120 days, they received melphalan, 200 cGy total body irradiation, immunosuppression with mycophenolate mofetil for 28 days, and cyclosporine for at least 56 days, followed by unmodified peripheral blood stem cell allograft from an HLA-identical sibling.
Simkins's doctor recommended that she undergo high dose chemotherapy with peripheral stem cell rescue (HDC/PSCR).
"Our results lead us to conclude that the routine practice of administering several cycles of conventional induction chemotherapy followed by a single course of high-dose chemotherapy and stem cell rescue cannot be recommended for women with metastatic breast cancer."
enough data: High-dose chemotherapy with autologous stem cell rescue for breast cancer.

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