stem cell mobilization


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stem cell mobilization

The stimulation of bone marrow (with intensive cancer chemotherapies or blood-forming growth factors) to release stem cells into the peripheral blood. The cells that appear in the blood can be harvested for use in autologous bone marrow transplantation. Mobilized cells (identified by the cell surface marker CD34) are returned to the patient after chemotherapy or radiation therapy so that the treated patient can ultimately resume making healthy blood cells on his own.
See also: mobilization
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References in periodicals archive ?
Currently, because the stem cell mobilization protocol is still considered experimental, it is not covered by insurance, making its $65,000 price tag out of reach for many patients.
These proposals supersede several existing patents on stem cell mobilization. Table 3 proposes a complex nutraceutical formulation that can be used in the support of stem cells.
This study involving human stem cell mobilization was triggered by a few cases of empirical evidence that consumption of an extract from AFA, enriched for the LSL, resulted in an unexpected extent of recovery after traumatic injuries to the central nervous system.
Food and Drug Administration for an Investigational New Drug (IND) application for the stem cell mobilization indication.
According to the company, the data presented highlight MGTA-145 as a promising first-line stem cell mobilization therapy for both autologous and allogeneic transplant that is differentiated from G-CSF, the current standard of care.
Ashraf, "IGF-1-overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1a/CXCR4 signaling to promote myocardial repair," Circulation Research, vol.
Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction.
The trial is designed to evaluate the ability of BL-8040, as a single agent, to promote stem cell mobilization for allogeneic transplantation.
CD34+ cells (whose mobilization in peripheral blood is a marker for hematopoietic stem cell mobilization) were measured in peripheral blood samples, and liver function was assessed before and after treatment, and at one, two, and three months.
A trial of the TI-CE protocol (two cycles of paclitaxel + ifosfamide for stem cell mobilization followed by three cycles of high-dose carboplatin and etoposide) reported a progression-free survival (PFS) of 48% at 5 years and a global survival of 52% (median survival of 61 months) (56).
Safety and efficacy of healthy volunteer stem cell mobilization with filgrastim G-CSF and mobilized stem cell apheresis: results of a prospective longitudinal 5-year follow-up study.
HBO could stimulate vasculogenic stem cell mobilization from bone marrow of diabetics and more cells are recruited to skin wounds to help healing [30, 31].