Currently, because the
stem cell mobilization protocol is still considered experimental, it is not covered by insurance, making its $65,000 price tag out of reach for many patients.
These proposals supersede several existing patents on
stem cell mobilization. Table 3 proposes a complex nutraceutical formulation that can be used in the support of stem cells.
This study involving human
stem cell mobilization was triggered by a few cases of empirical evidence that consumption of an extract from AFA, enriched for the LSL, resulted in an unexpected extent of recovery after traumatic injuries to the central nervous system.
Food and Drug Administration for an Investigational New Drug (IND) application for the
stem cell mobilization indication.
According to the company, the data presented highlight MGTA-145 as a promising first-line
stem cell mobilization therapy for both autologous and allogeneic transplant that is differentiated from G-CSF, the current standard of care.
Ashraf, "IGF-1-overexpressing mesenchymal stem cells accelerate bone marrow
stem cell mobilization via paracrine activation of SDF-1a/CXCR4 signaling to promote myocardial repair," Circulation Research, vol.
Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances
stem cell mobilization and angiogenesis after myocardial infarction.
The trial is designed to evaluate the ability of BL-8040, as a single agent, to promote
stem cell mobilization for allogeneic transplantation.
CD34+ cells (whose mobilization in peripheral blood is a marker for hematopoietic
stem cell mobilization) were measured in peripheral blood samples, and liver function was assessed before and after treatment, and at one, two, and three months.
A trial of the TI-CE protocol (two cycles of paclitaxel + ifosfamide for
stem cell mobilization followed by three cycles of high-dose carboplatin and etoposide) reported a progression-free survival (PFS) of 48% at 5 years and a global survival of 52% (median survival of 61 months) (56).
Safety and efficacy of healthy volunteer
stem cell mobilization with filgrastim G-CSF and mobilized stem cell apheresis: results of a prospective longitudinal 5-year follow-up study.
HBO could stimulate vasculogenic
stem cell mobilization from bone marrow of diabetics and more cells are recruited to skin wounds to help healing [30, 31].
