stem cell factor


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stem cell factor (SCF),

a cytokine that promotes growth and differentiation of hematopoietic stem cells into a variety of cell lineages.

stem cell factor

n.
A glycoprotein cytokine that promotes the differentiation and growth of hematopoietic stem cells into other types of cells.

KITLG

A gene on chromosome 12q22 that encodes KIT tyrosine kinase receptor ligand, which plays a key role in regulating cellular activities (such as: cell survival and proliferation; haematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration and function; and in melanogenesis) by activating multiple signalling pathways.

Molecular pathology
KITLG mutations cause familial progressive hyperpigmentation.

stem cell fac·tor

(stem sel fak'tŏr)
A cytokine that promotes growth and differentiation of hematopoietic stem cells into a variety of cell lineages.
References in periodicals archive ?
The expression of stem cell factor and c-kit receptor in human asthmatic airways.
The expression of stem cell factor and its receptor, c-kit in human endometrium and placental tissues during pregnancy.
It is clear that the expression of the stem cell factor gene results in the generation of specific signals to neighboring cells in the damaged heart resulting in improved outcomes at the molecular, cellular, and organ level," said Roger J.
Stem Cell Factor reduced the number of blood cell collection procedures required to help cancer patients overcome potentially toxic doses of chemotherapy.
They did this by using sophisticated gene sequencing methods to demonstrate a regulatory link between the stem cell factor Lin28 and the signaling molecule bone morphogenic protein 4 (BMP4).
The EFL ligands are normally linked to the cell surface and soluble forms of these ligands -- unlike soluble forms of other growth factors such as stem cell factor or nerve growth factor -- cannot activate their receptors.
Perhaps providing stem cell factors via injections of PRP or other growth factors may aid not only in hair regrowth but in preserving pigmentation and repigmentation.
They secrete a unique profile of stem cell factors and other important proteins.