The expression of stem cell factor
and c-kit receptor in human asthmatic airways.
Zander, "Stem cell factor
as a survival and growth factor in human normal and malignant hematopoiesis," Acta Haematologica, vol.
When the patients were treated with the drug imatinib (Glivec), which blocks the effect of stem cell factor
, the number of mature mast cells dropped, while the number of progenitor cells did not change.
Neopterin acting as a bone marrow stem cell factor
on early common haematopoietic (myeloid) and stromal (dendritic, CD34+) cell progenitors in vitro.
de Felici, "Stem cell factor
and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis)," Development, vol.
One study has shown that bronchial smooth muscle cells can express stem cell factor
, which may attract mast cells and stimulate their growth.
In [S.sub.1]/[S.sub.1d] mice that do not produce membrane-bound stem cell factor
, the ligand for kit, small intestinal ICCs at the level of the myenteric plexus are absent, suggesting that the stem cell factor
is necessary for their development. The major source of stem cell factor
is enteric neurons.
Therefore, the aim of the present study was to study the expression of hematopoietic regulatory molecules including macrophage inflammatory protein (MIP)-1[alpha], tumor necrosis factor (TNF)-[alpha], granulocyte colony-stimulating factor (G-CSF), stromal cell-derived factor (SDF)-1[alpha], stem cell factor
(SCF), and transforming growth factor (TGF)-[beta] by BM-MSCs of AA patients.
The proto-oncogene c-kit encodes a 145-kd transmembrane tyrosine kinase receptor (CD117), the ligand of which is stem cell factor
(SCF).[13-15] Expression of c-Kit is weak to moderate in a wide variety of normal, benign, and malignant tissues.[16-18] In a subset of mast cell disorders and gastrointestinal stromal cell tumors,[20,21] over-expression has been linked to either an activating or dominant-inactivating c-kit mutation.
On the contrary, other genes did not display significant changes though they code for cytokines or growth factors with a chemoattractant role on different types of stem cells, such as Cxcl12/Sdf1, stem cell factor
(SCF), Igf1, Hgf, Pdgfa, and Vegfa.
MALMO, Sweden, October 19, 2015 -- New research indicates that low levels of a growth factor called stem cell factor
(SCF)--which is thought to be important for blood vessel repair--are linked with an increased risk of cardiovascular disease.
In this method, CD34(+) or CD133(+) cells are cultured in serum-free medium containing VEGF, stem cell factor
(SCF), interleukin (IL)-6, Flt3 ligand, and thrombopoietin (TPO).