stem cell factor


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stem cell factor (SCF),

a cytokine that promotes growth and differentiation of hematopoietic stem cells into a variety of cell lineages.

stem cell factor

n.
A glycoprotein cytokine that promotes the differentiation and growth of hematopoietic stem cells into other types of cells.

KITLG

A gene on chromosome 12q22 that encodes KIT tyrosine kinase receptor ligand, which plays a key role in regulating cellular activities (such as: cell survival and proliferation; haematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration and function; and in melanogenesis) by activating multiple signalling pathways.

Molecular pathology
KITLG mutations cause familial progressive hyperpigmentation.

stem cell fac·tor

(stem sel fak'tŏr)
A cytokine that promotes growth and differentiation of hematopoietic stem cells into a variety of cell lineages.
References in periodicals archive ?
The expression of stem cell factor and c-kit receptor in human asthmatic airways.
Zander, "Stem cell factor as a survival and growth factor in human normal and malignant hematopoiesis," Acta Haematologica, vol.
When the patients were treated with the drug imatinib (Glivec), which blocks the effect of stem cell factor, the number of mature mast cells dropped, while the number of progenitor cells did not change.
Neopterin acting as a bone marrow stem cell factor on early common haematopoietic (myeloid) and stromal (dendritic, CD34+) cell progenitors in vitro.
de Felici, "Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis)," Development, vol.
One study has shown that bronchial smooth muscle cells can express stem cell factor, which may attract mast cells and stimulate their growth.
In [S.sub.1]/[S.sub.1d] mice that do not produce membrane-bound stem cell factor, the ligand for kit, small intestinal ICCs at the level of the myenteric plexus are absent, suggesting that the stem cell factor is necessary for their development.[37] The major source of stem cell factor is enteric neurons.
Therefore, the aim of the present study was to study the expression of hematopoietic regulatory molecules including macrophage inflammatory protein (MIP)-1[alpha], tumor necrosis factor (TNF)-[alpha], granulocyte colony-stimulating factor (G-CSF), stromal cell-derived factor (SDF)-1[alpha], stem cell factor (SCF), and transforming growth factor (TGF)-[beta] by BM-MSCs of AA patients.
The proto-oncogene c-kit encodes a 145-kd transmembrane tyrosine kinase receptor (CD117), the ligand of which is stem cell factor (SCF).[13-15] Expression of c-Kit is weak to moderate in a wide variety of normal, benign, and malignant tissues.[16-18] In a subset of mast cell disorders[19] and gastrointestinal stromal cell tumors,[20,21] over-expression has been linked to either an activating or dominant-inactivating c-kit mutation.
On the contrary, other genes did not display significant changes though they code for cytokines or growth factors with a chemoattractant role on different types of stem cells, such as Cxcl12/Sdf1, stem cell factor (SCF), Igf1, Hgf, Pdgfa, and Vegfa.
MALMO, Sweden, October 19, 2015 -- New research indicates that low levels of a growth factor called stem cell factor (SCF)--which is thought to be important for blood vessel repair--are linked with an increased risk of cardiovascular disease.
In this method, CD34(+) or CD133(+) cells are cultured in serum-free medium containing VEGF, stem cell factor (SCF), interleukin (IL)-6, Flt3 ligand, and thrombopoietin (TPO).