Ammonia produces pathological changes in human hepatic stellate cells
and is a target for therapy of portal hypertension.
Qu et al., "Pancreatic stellate cells
: partners in crime with pancreatic cancer cells," Cancer Research, vol.
Zheng et al., "Curcumin upregulates Nrf2 nuclear translocation and protects rat hepatic stellate cells
against oxidative stress," Molecular Medicine Reports, vol.
The targets of the drug are primarily associated with the activities of hepatic stellate cells
: the downregulation of cell activation [307-310], neutralization of fibrogenic and proliferative cell responses [311-313], promotion of cell apoptosis , and promotion of matrix degradation [315, 316].
Geerts, "History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells
," Seminars in Liver Disease, vol.
Alpha Mangostin Decreased Hepatic Stellate Cells
Activation as Shown by the Reduced Expression of [alpha]-SMA.
CYGB was discovered as a "stellate cell
activation-associated protein" and was expected to be useful as a molecular marker that revealed new aspects of the biological nature of Q-HSCs and the mechanisms underlying their activation.
Hepatic and pancreatic stellate cells
(HSCs and PSCs) are two types of nonparenchymal cells with long cytoplasmic processes giving them a typical stellate-shaped appearance.
According to the pathogenetic mechanism of hepatic fibrosis, the inhibition of hepatic fibrosis is mainly achieved through three pathways: inhibition or reduction of the damaging effects of harmful factors on hepatic cells; regulation of the expression of cytokines and related signaling proteins, inhibition of the activation of the immune cells or stellate cells
, or promotion of apoptosis; and inhibition of collagen hyperplasia or enhancement of collagen degradation.
A pilot study of the effects of D-alpha-tocopherol on hepatic stellate cell
activation in chronic hepatitis C.
showed that TQ treatment reduced the LPS-induced upregulation of COL1 Al and a-SMA in T-HSC/C1-6 cells, an immortalized rat hepatic stellate cell
line (Bai et al.
Marinosci et al., "Antifibrogenic effect of IFN-[alpha]2b on hepatic stellate cell
activation by human hepatocytes," Journal of Interferon & Cytokine Research, vol.