KITLG

(redirected from steel factor)

KITLG

A gene on chromosome 12q22 that encodes KIT tyrosine kinase receptor ligand, which plays a key role in regulating cellular activities (such as: cell survival and proliferation; haematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration and function; and in melanogenesis) by activating multiple signalling pathways.

Molecular pathology
KITLG mutations cause familial progressive hyperpigmentation.
References in periodicals archive ?
The KIT-ligand (steel factor) and its receptor c-KIT/W: pleiotropic roles in gametogenesis and melanogenesis.
Novel mutations and deletions of the KIT (steel factor receptor) gene in human piebaldism.
As a proof of the concept, HSCs in the device were exposed to a reduced concentration of a certain growth factor (steel factor, or SF) for various periods to see how long they could survive under these conditions before being rescued.
In the summer, the motor/diesel factor was linked to decreased HRV (SDNN), whereas in the winter, the combined motor vehicle/iron and steel factor was linked to increased HRV (rMSSD) (Figures 2B, 4B).
First, the corporation had no dividend history (not a Roth Steel factor).
The Appellate Court applied the Roth Steel factors (Roth Steel Tube Company v Commissioner, 800 F2d 625) that it had developed in a prior debt/equity decision and, in a split decision, determined that the Tax Court bad ignored some of those factors and misapplied others.