steatohepatitis


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Related to steatohepatitis: fatty liver, cirrhosis, Alcoholic Steatohepatitis

ste·a·to·hep·a·ti·tis

(stē'ă-tō-hep'ă-tī'tis),
Liver disease characterized by fatty change of hepatocytes, accompanied by intralobular inflammation and fibrosis; diagnozed microscopically in biopsy or autopsy specimens. Most often caused by alcohol abuse, diabetes, or obesity but may be linked to adverse drug reactions, gastrointestinal and pancreatic disorders or total parenteral nutrition. See NASH
See also: NASH.
[steato- + hepatitis]

steatohepatitis

A generic term for a fatty liver; with time, patients with steatohepatitis develop portal changes including interface hepatitis, increased portal inflammation and fibrosis, and ductular reaction. Some cases arise in a background of haemochromatosis.
References in periodicals archive ?
The company is currently conducting a Phase II trial with its drug candidate Namodenoson for the treatment of 60 patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis.
Lead researcher Professor Jose Quiles Morales, from the University of Granada, said: "The alterations caused by the long-term consumption of sunflower and fish oils make the liver susceptible to non-alcoholic steatohepatitis, a very serious disease that may act as a catalyst for other liver diseases such as cirrhosis and liver cancer.
Visit Non-alcoholic Steatohepatitis Biomarkers Market by Biomarker Type (Apoptosis Biomarkers, Hepatic Fibrosis Biomarkers, Oxidative Stress Biomarkers, Serum Biomarkers) and End User (Academics and Research Institute, Diagnostic Laboratories, Pharma and CROs, and Hospitals) and Forecast 2017-2021 at https://www.
Investigators randomized 101 individuals with biopsy-proven nonalcoholic steatohepatitis (NASH) and either prediabetes or type 2 diabetes to 18 months of 45 mg/day of pioglitazone or placebo, followed by an 18-month open-label phase of pioglitazone, in addition to a hypocaloric diet.
Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study.
Both studies involved people with nonalcoholic steatohepatitis (NASH), an aggressive disease characterised by fat in the liver.
USPRwire, Sat Mar 14 2015] GlobalData's clinical trial report, "Steatohepatitis Global Clinical Trials Review, H1, 2015" provides data on the Steatohepatitis clinical trial scenario.
Hepatic oxidative stress plays a key role in the development of non-alcoholic steatohepatitis (NASH), therefore, treatment approaches that address the antioxidant is helpful in the therapy of patients with NASH.
NAFLD represents a wide spectrum of liver damage ranging from simple non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), featuring steatosis, inflammation, cirrhosis, and hepatocellular carcinoma.
According to the firms, the facility will support the development of CVC for the treatment of nonalcoholic steatohepatitis and for working capital and general corporate needs.
and Italy monitored the weight gain and development of nonalcoholic fatty liver disease and its progression to nonalcoholic steatohepatitis in MSG-treated mice fed either a calorie-restricted or regular diet.
Editor's Note: Nonalcoholic fatty liver disease includes steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma, and can result in death if left untreated.