Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis
. Hepatology 2008; 47: 1936-46.
The inhibitory effect of miR-34a on peroxisome proliferator-activated receptor [alpha] (PPAR[alpha]), which functions to diminish the intake of fatty acid and facilitate lipoxidation, indicates it to be an important inducer of hepatocyte steatogenesis.
The circRNA_0046367 level even inversely correlated to both steatotic degree and intracellular TG content with statistical significance, suggesting a circRNA-dependent regulatory action throughout steatogenesis.
PPAR[alpha] downregulation, which further upregulates the SREBP-1c/PPAR[alpha] ratio, predisposes obese patients to insulin resistance and hepatic steatogenesis .
In contrast to its expression loss during steatogenesis, circRNA_0046367 normalization abolishes the miR-34a-induced PPAR[alpha] inhibition and hepatic steatosis.
Integrating significant GOs and the underlying pathways, circRNA-miRNA-mRNA network was constructed to identify the key circRNAs, and finally their action model, in steatogenesis.
circRNAs, therefore, are suggested to play a pathological role underlying the hepatic steatogenesis.
In consistence to their regulatory actions in metabolism , development , and carcinogenesis , circRNAs are finally highlighted to be robust transcriptional regulators during steatogenesis, probably in a counteracting manner.
Aflatoxin [B.sub.1]-induced hepatic steatosis: role of carbonyl compounds and active diols on steatogenesis
. Lancet 353:747-748.
Schirmacher, "Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis
," Hepatology, vol.