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re·leas·ing fac·tors (RF),
statinsDrugs of the hydroxymethyl glutaryl coenzyme A reductase inhibitor class (HMG-CoA reductase inhibitors). These drugs block the liver's production of cholesterol by competitive inhibition of the reductase coenzyme that catalyzes the rate-limiting step of cholesterol synthesis. They can lower the levels of low-density lipoproteins (LDLs) by 25–45 per cent and a number of major trials have shown their benefits in preventing heart attacks and other effects of ATHEROSCLEROSIS. They reduce the risk of sepsis and fatal sepsis in people with cardiovascular disease, and it has been established that intensive statin treatment after heart attacks provides greater protection against death than does a standard regimen. Recent research on mice has suggested that statins may have some value in MULTIPLE SCLEROSIS because of an effect of diminishing the cellular immune reponse. This growing drug class includes atorvastatin (Lipitor), cerivastatin (Liponay), fluvastatin (Lescol), pravastatin (Lipostat), rosuvastatin (Crestor) and simvastatin (Zocor). Note that the root ‘statin’ has proved popular with pharmacological neologists so, unfortunately, there are many other drugs, not in the HMG-CoA reductase inhibitor class, with ‘statin’ in their names.
statinsblood lipid-regulating drugs, e.g. atorvastatin, simvastatin, indicated as prophylactic therapy in patients with coronary or peripheral vascular disease, and in diabetic and hypertensive patients; 40mg daily reduces atherosclerotic plaque formation
Patient discussion about statins
Q. husband has horrible rash bil. below knees to his ankles. it is bright red yellow weeping cracks. On statins He has been on zocor for 15 years and we are so afraid this may have something to do with this drug. He has stopped taking the drug because the pain and weakness, and numbness in his legs is considerable