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Any of a class of lipid-lowering drugs that reduce serum cholesterol levels by inhibiting a key enzyme involved in the biosynthesis of cholesterol.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


A popular term for a HMG-CoA reductase inhibitor, which ↓ cholesterol–eg, pravastatin, lovastatin, etc, which ↓ progression of ASHD/CAD, even in absence of ↑ cholesterol. See Atorvastatin, Cervastatin, Fluvastatin, Lovastatin, Pravastatin, Simvastatin.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


(stat'in) [ -stat + -in]
Any of the drugs of the class known as 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors. These drugs have powerful lipid-lowering properties. The names of drugs in this class all end in “-statin” (e.g., atorvastatin, pravastatin, rosuvastatin, and simvastatin). Drugs from this class reduce the risk of myocardial infarction and stroke. Synonym: HMG CoA enzyme inhibitor
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Patient discussion about statin

Q. husband has horrible rash bil. below knees to his ankles. it is bright red yellow weeping cracks. On statins He has been on zocor for 15 years and we are so afraid this may have something to do with this drug. He has stopped taking the drug because the pain and weakness, and numbness in his legs is considerable

A. i looked up for side effects and i saw only "eczema" as a skin side effect. but it seems odd to me that after 15 years you got this kind of side effect. it should have appeared years ago. you know- it might be a very good idea to go and see a Dr... and not stopping a medication without warning..

More discussions about statin
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References in periodicals archive ?
It could help doctors prevent a known side effect of statins and ensure people are able to reap the benefits of the life-saving drugs.
Some treatable conditions (such as thyroid dysfunction and severe vitamin D deficiency) may contribute to statin intolerance, as may consuming large quantities of grapefruit products and use of certain medications.
A team of scientists funded by the British Heart Foundation (BHF) found that statins cause spontaneous and irregular leaks of calcium from storage compartments within muscle cells.
A team of researchers funded by the British Heart Foundation (BHF) found that statins cause spontaneous and irregular leaks of calcium from storage compartments within muscle cells.
BY POPPY DANBY COMING off statins could increase the risk of a heart attack in healthy over-75s by almost half, it has emerged.
Over the past 30 years, there has been confusion over side-effects, fear of dementia risks, and claims that statins simply don't work.
Tendinopathy is another side effect related to statin treatment and is frequent in patients with diabetes, hyperuricaemia, history of tendon disorders, and in persons involved in active sports.6,16 Tendinopathy was first reported in four patients in 2001.
The researchers found that a higher prevalence of elevated hemoglobin A1c occurred among incident statin users without diabetes.
Last year, a clinical trial partfunded by the BHF suggested patients report more side effects when they know they're being given a statin, than when they don't know what they're taking.
As for statin therapy in patients with end-stage renal failure or severe hepatic disease, starting treatment is not recommended.
Although statin use is associated with a mild, rare, reversible delirium, it isn't linked to permanent cognitive decline (SOR: C, expert opinion).
It is clear that the preventive benefits of statin therapy are likely to outweigh the limited increase in HZ risk in many cases, (but) this evidence should be taken into account by GPs when prescribing statins to those at high risk of HZ.