statin

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statin

(stăt′n)

Any of a class of lipid-lowering drugs that reduce serum cholesterol levels by inhibiting a key enzyme involved in the biosynthesis of cholesterol.

–statin

A popular term for a HMG-CoA reductase inhibitor, which ↓ cholesterol–eg, pravastatin, lovastatin, etc, which ↓ progression of ASHD/CAD, even in absence of ↑ cholesterol. See Atorvastatin, Cervastatin, Fluvastatin, Lovastatin, Pravastatin, Simvastatin.

statin

(stat'in) [ -stat + -in]

Any of the drugs of the class known as 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors. These drugs have powerful lipid-lowering properties. The names of drugs in this class all end in “-statin” (e.g., atorvastatin, pravastatin, rosuvastatin, and simvastatin). Drugs from this class reduce the risk of myocardial infarction and stroke. Synonym: HMG CoA enzyme inhibitor

Patient discussion about statin

Q. husband has horrible rash bil. below knees to his ankles. it is bright red yellow weeping cracks. On statins He has been on zocor for 15 years and we are so afraid this may have something to do with this drug. He has stopped taking the drug because the pain and weakness, and numbness in his legs is considerable

A. i looked up for side effects and i saw only "eczema" as a skin side effect. but it seems odd to me that after 15 years you got this kind of side effect. it should have appeared years ago. you know- it might be a very good idea to go and see a Dr... and not stopping a medication without warning..

More discussions about statin

References in periodicals archive ?

It could help doctors prevent a known side effect of statins and ensure people are able to reap the benefits of the life-saving drugs.

University of Leeds: Scientists identify potential cause of statin-related muscle pain

Some treatable conditions (such as thyroid dysfunction and severe vitamin D deficiency) may contribute to statin intolerance, as may consuming large quantities of grapefruit products and use of certain medications.

Life on Statin Therapy: What You Should Expect: From their cardiovascular benefits to their potential side effects, here's what you need to know about these cholesterol medications

A team of scientists funded by the British Heart Foundation (BHF) found that statins cause spontaneous and irregular leaks of calcium from storage compartments within muscle cells.

Exercise could be key for statins patients; MEDICINE

A team of researchers funded by the British Heart Foundation (BHF) found that statins cause spontaneous and irregular leaks of calcium from storage compartments within muscle cells.

Calcium leaks linked to statin pain

BY POPPY DANBY COMING off statins could increase the risk of a heart attack in healthy over-75s by almost half, it has emerged.

The truth about statins... Guide to cholesterol drug

Over the past 30 years, there has been confusion over side-effects, fear of dementia risks, and claims that statins simply don't work.

The truth about statins... Guide to cholesterol drug

Tendinopathy is another side effect related to statin treatment and is frequent in patients with diabetes, hyperuricaemia, history of tendon disorders, and in persons involved in active sports.6,16 Tendinopathy was first reported in four patients in 2001.

Can alternate-day Statin regimen minimize its adverse effects on muscle and tendon? A systematic review

The researchers found that a higher prevalence of elevated hemoglobin A1c occurred among incident statin users without diabetes.

Statin Use Associated With Higher Incidence of Diabetes; Findings show statin use tied to higher HbA1c values, with longer statin use tied to greater risk for diabetes

Last year, a clinical trial partfunded by the BHF suggested patients report more side effects when they know they're being given a statin, than when they don't know what they're taking.

Statins: What's the debate all about? Many doctors think cholesterol-lowering statins are lifesavers - but not everyone agrees. LISA SALMON finds out more

As for statin therapy in patients with end-stage renal failure or severe hepatic disease, starting treatment is not recommended.

AHA: Statins associated with high degree of safety

Although statin use is associated with a mild, rare, reversible delirium, it isn't linked to permanent cognitive decline (SOR: C, expert opinion).

Q / Do statins alter the risk or progression of dementia?

It is clear that the preventive benefits of statin therapy are likely to outweigh the limited increase in HZ risk in many cases, (but) this evidence should be taken into account by GPs when prescribing statins to those at high risk of HZ.