start codon


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Related to start codon: stop codon

in·i·ti·a·ting co·don

the trinucleotide AUG (or sometimes GUG) that codes for the first amino acid in protein sequences, formylmethionine; the latter is often removed post-transcriptionally.
Synonym(s): start codon

start codon

n.
A codon, AUG in eukaryotes and either GUG or UUG in bacteria, that signals the initiation of translation and the first amino acid in a polypeptide chain. Also called chain initiation codon.
References in periodicals archive ?
AT, G...) in the false start codon ATG, as shown in Figure 2(c).
Start codon targeted (SCoT) and target region amplification polymorphism (TRAP) for evaluating the genetic relationship of Dendrobium species.
Additionally, eIF3 and PABP bind synergistically with in vitro-transcribed, uncapped, and poly(A)-tailed XIAP IRES RNA and recruit ribosomes near the start codon [12] (Figure 3).
Vitamin D receptor start codon polymorphism (FokI) is related to bone mineral density in healthy adolescent boys.
Examination of individual eubacterial genomic sequence patterns and the eubacterial average over all reported ORFs (Figure 1) reveals distinctive patterns near the start codon. The averaged start codons themselves show the expected overwhelming presence of A, T, and especially G in the third position (base number 2 in the representation used).
A silent mutation was found at base pair #328 following the start codon) and a point mutation was found at base pair #542 (following the start codon) (Figure 3).
Thus when activated by DNA-binding proteins, the enhancer-promoter interaction is the control switch that initiates transcription by signaling the RNA polymerase to bind to the promoter and start codon ATG.
Given that AUG sequences occur randomly throughout a given mRNA, could one of these sequences act as a start codon if positioned at or near the 5' terminus of a message, and how commonly are AUG sequences found in such a position?
A G/A transition found in codon 108/158 (depending on the used start codon) results in a valine-to-methonine substitution (GenBank accession No.
Direct sequencing of all 11 exons of PRKAR1A of this patient identified a 88 A to G mutation, which changes the initiator ATG to a GTG codon, abolishes the translational start codon but does not introduce a premature stop codon [Figure 1]e.
We now identified m1A which decorates thousands of genes mainly in the start codon vicinity, upstream to the first splice site.
The presence of a U insertion downstream to the second possible start codon for ORF2 (AUG2) in DcHEV strain 178C resembled the presence of a U insertion in HEV4 and wild boar HEV, leading to 3 possible start codons for its ORF2 but 1 possible start codon for its ORF3; whereas, the lack of this U insertion downstream to AUG2 in DcHEV strain 180C resembled the lack of U insertions in HEV1, HEV2 and HEV3, leading to only 1 possible start codon for its ORF2 but 3 possible start codons for its ORF3.