CACNG2

(redirected from stargazin)

CACNG2

A gene on chromosome 22q13.1 that encodes a gamma subunit of a voltage-dependent calcium channel, which regulates AMPA-selective glutamate receptor (AMPAR) trafficking and gating. It promotes
AMPAR targeting to the cell membrane and synapses, and it modulates their gating properties by slowing their activation, deactivation and desensitisation.
References in periodicals archive ?
(2015) Glutamate-induced AMPA receptor desensitization increases their mobility and modulates shortterm plasticity through unbinding from stargazin. Neuron 85, 787-803.
Tigaret et al., "CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin," Neuron, vol.
What e time is e stargazin dinner, p Dark - w spread t can and What else you do during that time is entirely up to you.
MAG12 encodes for a scaffolding protein membrane-associated guanylate kinase which interacts with stargazin, a protein implicated in severe epilepsy in the stargazer mouse.
The PDZ domain of PSD-95 binds to different postsynaptic proteins; for example, PDZ2 interacts with NR2 and NR1 of NMDARs [246] and stargazin interacts with PDZ1 and PDZ2 of PSD-95 to regulate AMPAR synaptic numbers [247].
Sekiguchi et al., "Stargazin modulates AMPA receptor gating and trafficking by distinct domains," Nature, vol.