staphylokinase


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staphylokinase

 [staf″ĭ-lo-ki´nās]
a bacterial kinase produced by certain strains of staphylococcus; it induces fibrinolysis by converting plasminogen to plasmin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

staph·y·lo·ki·nase

(staf'i-lō-kī'nās),
A bacterial nonenzymatic activator of plasminogen; not to be confused with aureolysin.
Farlex Partner Medical Dictionary © Farlex 2012

staph·y·lo·ki·nase

(staf'i-lō-kī'nās)
A microbial metalloenzyme from Staphylococcus aureus, with action similar to that of urokinase and streptokinase, which can convert plasminogen to plasmin but requires Ca2+; separated in forms A, B, and C.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
(1,2) There is an apparent association between the pathogenesis of MRSA strains and the expression of virulence factors such as cell surface components (e.g., collagen-binding protein, clumping factor, fibronectin-binding protein, and elastin-binding protein) and secreted factors (e.g., staphylokinase, toxic shock syndrome toxin-1, hemolysin, Panton-Valentine leukocidin (PVL), exfoliative toxins (eta, etb), staphylococcal enterotoxins, and lipase).
The method includes four phenotypic tests: production of staphylokinase (K), [beta]-haemolysin ([beta]), coagulation of bovine plasma (BPC), and growth on crystal violet agar (CV) (Table 1).
Staphylokinase (SAK) is a secreted protein that binds and activates surface-bound plasminogen into plasmin, which removes IgG as well as C3b from the bacterial surface, making this protein a unique antiopsonic molecule [67].
This system regulates the expression of surface proteins (protein A) and secreted toxins (toxic shock syndrome toxin, hemolysin, and staphylokinase) [47].
Biotyping was carried out according to the simplified scheme [6,7,13], which uses four discriminative tests: the production of staphylokinase and [beta]-haemolysin, the coagulation of bovine plasma within 6 h and the type of growth on crystal violet agar.
Streptokinase and staphylokinase. Methods Enzymol 1981;80:387-394.
Indirect activators include substances such as streptokinase and staphylokinase, which are produced by bacteria and bind to plasminogen to form an activator complex that then cleaves other plasmino-gen molecules to plasmin.
Blood Coagulation and Fibrinolysis accomplished by serine proteases [32], Plasminogen activator, exogenous therapeutic activators or foreign activators are enzymes and enzyme activators used to accelerate clot [33] foreign activators are bacterial streptokinase, staphylokinase etc.
Another thrombolytic protein, Staphylokinase has been licensed to M/S Strides Arcolab Ltd., Bangalore.