(1,2) There is an apparent association between the pathogenesis of MRSA strains and the expression of virulence factors such as cell surface components (e.g., collagen-binding protein, clumping factor, fibronectin-binding protein, and elastin-binding protein) and secreted factors (e.g., staphylokinase
, toxic shock syndrome toxin-1, hemolysin, Panton-Valentine leukocidin (PVL), exfoliative toxins (eta, etb), staphylococcal enterotoxins, and lipase).
Screening for staphylokinase
producing Staphylococcus spp.
The method includes four phenotypic tests: production of staphylokinase
(K), [beta]-haemolysin ([beta]), coagulation of bovine plasma (BPC), and growth on crystal violet agar (CV) (Table 1).
(SAK) is a secreted protein that binds and activates surface-bound plasminogen into plasmin, which removes IgG as well as C3b from the bacterial surface, making this protein a unique antiopsonic molecule .
This system regulates the expression of surface proteins (protein A) and secreted toxins (toxic shock syndrome toxin, hemolysin, and staphylokinase
Biotyping was carried out according to the simplified scheme [6,7,13], which uses four discriminative tests: the production of staphylokinase
and [beta]-haemolysin, the coagulation of bovine plasma within 6 h and the type of growth on crystal violet agar.
Streptokinase and staphylokinase
. Methods Enzymol 1981;80:387-394.
Indirect activators include substances such as streptokinase and staphylokinase
, which are produced by bacteria and bind to plasminogen to form an activator complex that then cleaves other plasmino-gen molecules to plasmin.
Blood Coagulation and Fibrinolysis accomplished by serine proteases , Plasminogen activator, exogenous therapeutic activators or foreign activators are enzymes and enzyme activators used to accelerate clot  foreign activators are bacterial streptokinase, staphylokinase
Another thrombolytic protein, Staphylokinase
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