standard urea clearance

stan·dard u·re·a clear·ance

the value obtained when the square root of the urine flow (when below 2 mL/min) is multiplied by the urine urea concentration and divided by the whole blood urea concentration; represents an old empiric adjustment for the effect of low urine flow on urea excretion; sometimes corrected for body size by dividing by some function of body weight or surface area. Later, plasma concentration was substituted for blood concentration in the calculation. The normal value is about 54 mL per minute per 1.73 m2 in an adult.
Synonym(s): Van Slyke formula

Van Slyke,

Donald D., U.S. biochemist, 1883-1971.
slyke - a unit of buffer value, the slope of the acid-base titration curve of a solution.
Van Slyke apparatus - determines the amount of respiratory gases in the blood.
Van Slyke formula - the value obtained when the square root of the urine flow is multiplied by the urine urea concentration and divided by the whole blood urea concentration. Synonym(s): standard urea clearance
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