Along with these, patients had either stainable iron
in the bone marrow macrophages with reduced/absent siderocytes and sideroblasts and a raised ESR or CRP.
A bone marrow report of absent stainable iron
is not diagnostic of iron deficiency.
A number of markers like serum ferritin, serum iron, total iron binding capacity, and transferrin saturation are used to assess the iron status of the individual, (3) but microscopic examination of the stainable iron
in the bone marrow is considered the gold standard for determining the body iron stores.
They were subjected to liver biopsies which were assessed for grade, stage, steatosis, stainable iron
and characteristic histological lesions.
16-19) In these studies, an absence of stainable iron
, grade 0 or 1, almost invariably corresponded to HIC below the mean value for the control group; grade 2 represented mild but significantly increased iron stores with HIC values of 1.
In patients who have stainable iron
in the bone marrow an elevated plasma transferrin receptor value may reflect functional iron deficiency.
One study of adults compared the diagnostic power of the CHr with SF and TS in 78 patients, 28 of whom were iron deficient based on lack of stainable iron
on bone marrow smears.
We investigated the pharmacokinetic disposition and bioavailability of deferiprone in the white leghorn chicken, a species that can be intravenously iron loaded, has no stainable iron
in the liver of healthy birds, (32) and is large enough for the multiple blood collections required for a pharmacokinetic study.
Serum iron, total iron binding capacity, ferritin, hemosiderin, ferrokinetics and free erythrocyte protophorin are among further tests that could be done to assess and treat cases of lead poisoning in children in addition to bone marrow tests, such as: stainable iron
stores, erythrocyte cellularity, sideroblast % and hemoglobin electrophoresis for Hb A2 and Hb F which increases during lead poisoning.
Bone marrow studies in patients with CKD undergoing hemodialysis have indicated little or no stainable iron
at levels greater than 100 ng/mL, particularly in a setting of inflammation (Fernandez-Rodriguez et al.
Laboratory abnormalities encountered in HH include increased levels of alanine and aspartate aminotransaminases, or AST/ALT, elevated serum iron transferrin saturation (>60%), increased serum ferritin, and higher amounts of hepatic parenchymal cell stainable iron
The IDA group consisted of 32 anemic patients who had no stainable iron
in the bone marrow.