squamous intraepithelial neoplasia

A generic term for the range of premalignant lesions of the oral squamous epithelium, which follows the widely used nomenclature of the uterine cervix. SIN 1 corresponds to the 2005 WHO classification’s mild dysplasia, SIN 2 to moderate dysplasia and SIN 3 to the WHO’s severe dysplasia and carcinoma in situ.

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Anal squamous cell carcinoma is relatively rare in the general population but very much on the rise in certain populations including human immunodeficiency virus (HlV)-positive men and women, men who have sex with men (MSM), patients immunosuppressed for other reasons including solid organ transplant or autoimmune disease, and women with multifocal lower genital tract squamous intraepithelial neoplasia. The American Cancer Society's estimates for anal cancer in the United States for 2017 are approximately 8200 new cases with about 1100 deaths (650 women and 450 men).

Anal Cytology: Institutional Statistics, Correlation With Histology, and Development of Multidisciplinary Screening Program With Review of the Current Literature

Caption: Cervical squamous intraepithelial neoplasia 3 is shown on a cervical gland.

Real-world data support extended cervical cancer screening interval

Stages of anal cell abnormalities * Normal anal all * Atypical squamouscells of undetermined significance * Low-grade squamous Intraepithellal neoplasia * Atypical squamouscellls,cannot exclude HSIL * High-grade squamous intraepithelial neoplasia * Invasive anal cancer Figure 2.

Abnormal anal cells that could lead to cancer common in gay men with HIV

Additionally, women who present high grade vulvar squamous intraepithelial neoplasia, vulvar cancer or cervical cancer must be part of this group, which corresponds to the absolute indications for anal cytology (Box 2).

HPV infection and intraepithelial lesions from the anal region: how to diagnose?

Screening cytology carries a high specificity for detecting high-grade and low-grade squamous intraepithelial neoplasia (HSIL and LSIL), which leads to proper treatment.

HPV: a look into new methods for high-risk testing

Frequency of occult high-grade squamous intraepithelial neoplasia and invasive cancer within anal condylomata in men who have sex with men.

Pre-cancerous cell changes "hidden" in anal warts of gay men, US

(22) Among men, risk factors for anal squamous intraepithelial neoplasia include HPV infection, as well as higher numbers of male partners for receptive anal intercourse in the previous 6 months, and the use of illegal drugs, such as alkyl nitrites and injection drugs.

Epidemiology and natural history of HPV

On cytology, squamous intraepithelial neoplasia and VAIN "look exactly the same," he added.

Vaginal intraepithelial neoplasia difficult to spot: 'a fair number of patients' have vaginal, cervical, and vulvar intraepithelial neoplasia simultaneously

The World Health Organization (WHO) 2017 classification formally reused the term dysplasia, (2) rather than the previously proposed terms squamous intraepithelial neoplasia (SIN), (3,4) squamous intraepithelial lesion (SIL), (5) or laryngeal intraepithelial neoplasia.

Recent Changes of Classification for Squamous Intraepithelial Lesions of the Head and Neck

Eosinophilic dysplasia of the cervix: a newly recognized variant of cervical squamous intraepithelial neoplasia. Am I Surg Pathol.

Variability of Pathologists' Utilization of p16 and Ki-67 Immunostaining in the Diagnosis of Cervical Biopsies in Routine Pathology Practice and Its Impact on the Frequencies of Cervical Intraepithelial Neoplasia Diagnoses and Cytohistologic Correlations

of Positive for Follow-up Diagnosis Women Aptima HPV, % Cytology only Normal 189 57 LSIL 18 78 ASCUS 5 80 Total 212 59 Histology Normal 35 57 CIN 1 91 69 CIN 2 34 91 CIN 3 31 94 Adenocarcinoma in situ 1 100 Adenocarcinoma 1 100 Total 193 75 Abbreviations: ASCUS, atypical squamous cells of undetermined significance; CIN, cervical squamous intraepithelial neoplasia; HPV, human papillomavirus; LSIL, low-grade squamous intraepithelial lesion.

Clinical performance of a human papillomavirus messenger RNA test (aptima HPV assay) on residual material from archived 3-year-old PreservCyt samples with low-grade squamous intraepithelial lesion