Another caveat is that increased p53 staining can be seen in 5% to 61% of LS and LSC cases, and up to 40% of squamous cell hyperplasia cases.
(1) Squamous cell hyperplasia is usually considered a diagnosis of exclusion because it is frequently seen adjacent to LS, dVIN, and invasive squamous cell carcinoma.
In our case, pathological examination revealed a high-grade invasive squamous cell carcinoma, with squamous cell hyperplasia
and verrucous carcinoma.
Mild to moderate proliferative changes were only detected in the forestomach of 4 rats (28.6%) in the AL group, whereas all the rats in the AC group developed mild to severe squamous cell hyperplasia
and this progressed to SCC in one case in the AC group (Figure 2) (Table 1).
Histopathological examination of the resected uterus revealed uterine fibroids endometrial atrophy chronic cervical inflammation squamous cell hyperplasia
localized low-grade CIN I and interstitial gland tumor-like hyperplasia (Fig.1B C).