sporozoite


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Related to sporozoite: merozoite, sporogony

sporozoite

 [spor″o-zo´īt]
a spore formed after fertilization; any one of the sickle-shaped nucleated germs formed by division of the protoplasm of a spore of a sporozoan organism. In malaria, the sporozoites are the forms of the plasmodium that are liberated from the oocysts in the mosquito, that accumulate in the salivary glands, and that are transferred to humans when the mosquito feeds.

spo·ro·zo·ite

(spō'rō-zō'īt),
One of the minute elongated bodies resulting from the repeated division of the oocyst during sporogony. In the case of the malarial parasite, it is the form that is concentrated in the salivary glands and introduced into the blood by the bite of a mosquito; it enters the liver cells (exoerythrocytic cycle), the progeny of which, the merozoites, infect the red blood cells to initiate clinical malaria.
[sporo- + G. zōon, animal]

sporozoite

(spôr′ə-zō′īt′)
n.
Any of the cells that are released from the oocyst of an apicomplexan parasite and invade a new host cell.

spo·ro·zo·ite

(spōr'ō-zō'īt)
One of the minute elongated bodies resulting from the repeated division of the oocyst during sporogony. In the case of the malarial parasite, it is the form that is concentrated in the salivary glands and introduced into the blood by the bite of a mosquito; it enters the liver cells (exoerythrocytic cycle); its progeny, the merozoites, infect the red blood cells to initiate clinical malaria.
[sporo- + G. zōon, animal]

sporozoite

A motile reproductive form of a SPOROZOON that has been released from an oocyst and is ready to penetrate a new host cell, as in malaria transmission.

sporozoite

any of the very small mobile spores formed by multiple fission of a protozoan zygote, as in the MALARIA PARASITE.
References in periodicals archive ?
During their obligatory blood meals, infected female Anopheles mosquitoes inject sporozoites belonging to Plasmodium falciparum species into the human dermis [6].
Sporozoites then invade hepatocytes by using cholesterol uptake pathway [6].
Animals treated with a single IM-DQ microsuspension injection at a single dose of 120 mg/kg were shown to have full causal prophylaxis during treatment periods of 2-8 weeks prior to sporozoite challenge (Table 1).
falciparum sugar transporter (PfHTl--PF3D7_0204700) is expressed in all the life cycle stages examined, while the divergent gene (PF3D7_0919500) is only detected in sporozoites (Table 1).
Rosenberg, "Inability of Plasmodium Knowlesi sporozoites to invade Anopheles freeborn salivary glands," The American Journal of Tropical Medicine and Hygiene, vol.
Hence, this paper presents the assessment of potency of the sporozoites of E.
Extensive screens for fail-proof stocks of NF54, 3D7, and 7G8 were undertaken, mass sporozoite harvesting methods were adopted, and individualized fine-tuning of each round of parasite culture/mosquito infection was abandoned in favor of a scheduled, standardized culture/ rearing/infection regimen used for every round of production (Figure 1).
When mice deficient in either IRF-3 or IRF-7 were infected with PbA sporozoite, significant impairment in IFN-I response was observed.
The PfSPZ Vaccine is composed of live but weakened sporozoites of the species Plasmodium falciparum, the most deadly of the malaria-causing parasites.
Thereby, the approach used during the last two to three decades to design a malaria vaccine has been based on identifying "subunits" of the parasite, such as complete antigens or their fragments, which have been mainly produced as synthetic peptides and recombinant proteins derived from sporozoite, merozoite, or gametocyte stages.
Marc, "Levels of antibodies to Plasmodium falciparum sporozoite surface antigens reflect malaria transmission rates and are persistent in the absence of reinfection," Infection and Immunity, vol.
If the sporozoite injected by a mosquito into a human host develops directly into a tissue schizont, the incubation period between the initial infection and the onset of symptoms is short, typically from 10 days to 4 weeks, resulting in an early primary attack.