spontaneous agglutination

spon·ta·ne·ous ag·glu·ti·na·tion

nonspecific clumping of organisms in saline related to lack of polar groups in electrolyte solution.
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Patients with AIHA and warm RBC autoantibodies do not have the spontaneous agglutination of RBCs but can still have significant hemolysis as the RBCs coated with autoantibodies are removed by the reticuloendothelial system, which also presents with signs and symptoms of anemia and hemolysis.
Cold RBC autoantibodies can cause spontaneous agglutination, observed as clumping of the RBCs on the test (Figure, B).
To check for spontaneous agglutination of the bacterial cells, phosphate-buffered saline was tested with each isolate.