The second objective aims at clarifying the basis of prion neurotoxicity and will be developed along two alleys: (a) we will uncover the molecular basis of spongiosis
(the neuronal vacuolation characteristic of prion diseases), which we suspect to be a main driver of pathology, and (b) we will perform CRISPR-based synthetic lethality screens to identify genes that become essential to prion-infected cell lines (which do not experience prion toxicity) and may not be expressed by neurons.
Characteristic histopathologic features were nonspecific perivascular cuffing, rod cell proliferation, spongiosis
, neuronal necrosis, moderate to severe gliosis, neuronal satellitosis, and neurophagia.
The first study found that topical fluticasone therapy at a dose of 880 mcg twice daily for 2 months helped correct esophageal spongiosis
, or dilated intercellular space, in patients with eosinophilic esophagitis (EoE).
Hyperintense signals in the basal ganglia and the cortex observed bilaterally on cranial MRIs are the result of spongiosis
The earliest change appears be a focal area of mild spongiosis
that spreads centrifugally.
The cortical bone tissue was modeled to match the bone type I, according to the classification by Lekholm and Zarb, encompassing the spongiosis
bone by 2 mm.
Certain features, such as predominate lymphocytic infiltrate, were always correctly identified, whereas other features, such as parakeratosis and spongiosis
, were never reported by the residents.
Other findings within the central nervous system included multifocal vacuolation and separation of white matter fibers consistent with spongiosis
throughout the spinal cord.
otoimmun bulloz hastaliklar icerisinde pemfigus vegetans, pemfigus foliaceus, pemfigus herpetiformis, bulloz pemfigoid, pemfigoid gestasyonesde gorulebilen bir bulgudur (1).
The brain sections were examined for gliosis, spongiosis
, inflammatory infiltrate, oedema and meningeal changes.
T cell-mediated effector functions such as epithelial shedding and spongiosis
formation depends on IFN-[gamma],TNF-[alpha] and Fas-ligand production in the skin and lung.
A biopsy in difficult cases will show squamous hyperplasia, spongiosis
, hyperkeratosis, and sometimes erosion with associated acute and chronic inflammation.