(4) Blaschkitis is a term for a blaschkoid inflammation of the skin that presents with more eczematous findings and histology of spongiosis
, unlike the lichenoid findings of LS.
(15) Prominent intercellular bridges (spongiosis
or acantholysis) and superficial premature cells with eosinophilic cytoplasm can also be appreciated.
found that addition of IL-4, IL-13, IL-31, and TNF-a during generation of the skin equivalents induces intercellular edema (spongiosis
), altered expression of epidermal differentiation proteins, and secretion of thymic stromal lymphopoietin, which is a master regulator of Th2-driven inflammation by keratinocytes (Danso et al., 2014).
 OKC is characterized, histologically, by a palisaded basal cell layer of basophilic columnar cells and a surface of corrugated parakeratin, sometimes with spongiosis
, resembling closely the stellate like reticulum and the acanthomatous differentiation of Ameloblastoma.
In the brain stem (Figure 1B), the pons and the medulla oblongata had marked spongiosis
in white matter tracts.
Histologic analysis of biopsy specimens of skin lesions in irritant CD and allergic CD shows nonspecific pictures, usually including spongiosis
, spongiotic bubbles, numerous neutrophils in the epidermis, swollen capillaries in the subepidermal dermis, and peri-vascular lymphocytic infiltrates (29) (Figs.
Histopathological examination showed significant swelling of intracellular cells of the spiny and basal layer (spongiosis
), as well as accumulation of polymorphonuclear leukocytes in the stratum corneum.
Hypertrophied astrocytes with scant cytoplasm, vesicular nucleus, marginated chromatin were frequently observed in pairs (Alzheimer type II astrocytes); and also severe vacuolization in the white matter of the brain, cerebellum and brain stem (spongiosis
) was found (FIG.
of the cerebral cortex is observed in some cases, but is either moderate or sometimes absent, especially in cases with a short disease course. Parchi et al.
The histopathological features showed presence of mucous cells, vacuolated cells, spongiosis
, micro-abscesses, cholesterol crystals, hemosiderin and inflammatory infiltrate.
Residual cerebellar grey matter within the area of encephalomalacia displayed generalized gliosis, numerous prominent reactive blood vessels, gitter cell infiltration, spongiosis
, and dystrophic mineralization.
In addition, [PrP.sup.Sc] deposits also involved areas less often affected or not affected by spongiosis
, such as the nucleus of the solitary tract (Figure 1, panel E); the hypoglossal nucleus; pyramidal cells of hippocampus; the granular layer of cerebellum, including Purkinje cells (Figure 1, panel F); and several white matter areas.