Histology is non-specific and shows focal spongiosis
and exocytosis in the epidermis with a mixed dermal inflammatory infiltrate.
Histopathologic analysis of photoallergic reactions also includes epidermal spongiosis
and dermal lymphocytic infiltrate, with necrotic keratinocytes, which is suggestive of photoallergy.
3%), Focal acanthosis in 48 cases (80%), Spongiosis
in 38 cases (63.
Panels show multifocal mild to severe perivascular and neuropil infiltration of lymphocytes and monocytes (blue arrows in A-C); meningitis in a sulcus (black arrow in A); glial cell activation with notable astrocytosis, neuron degeneration, and neuronophagia (arrowhead in B); occasional hemorrhage (blue arrow in D); mild periventricular spongiosis
(blue arrows in C); and meningitis (black arrow in C).
For histopathological features of AD-like GVHD patients, the epidermal changes included hyperkeratosis, parakeratosis, epidermal spongiosis
, and scattered keratinocyte necrosis.
Examination of the biopsy specimen obtained from the knee revealed regular acanthosis and hypogranulosis, mild spongiosis
, and intraepidermal clusters of neutrophils (Munro's microabscess) in the epidermis, and the diagnosis of psoriasis was confirmed.
110) The resulting chronic blockade of protein synthesis leads to synaptic failure, spongiosis
, and neuronal loss.
904 mg/kg LiCl over the course of 8 days, the vacuolization of the brain tissue and zones of spongiosis
were observed in different brain regions, including cerebral cortex, cerebellum, medulla oblongata, mesencephalon, thalamus, and pons .
The team also observed basal cell and papillary hyperplasia and areas of spongiosis
, even though the surface cells were still intact.
Histologically, bed bug bites resemble perivascular eosinophilic infiltrates through the superficial and deep dermis, with minimal spongiosis
Dermatologists rarely biopsy an eczematous lesion to differentiate between clinical variants of spongiotic dermatitis, so it is sufficient for the pathologist to recognize epidermal spongiosis
and to classify the inflammatory reaction pattern as "spongiotic.
The biopsy of the lesions shows unspecified and variable findings, but they usually share the presence of vacuolar interfase dermatitis, spongiosis
, and a superficial lymphocytic infiltrate with occasional eosinophiles (37,38).