SF3B1

(redirected from splicing factor 3B subunit 1)

SF3B1

A gene on chromosome 2q33.1 that encodes subunit 1 of the splicing factor SF3B, which is required for “A” complex assembly by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Binding of the SF3A/SF3B complex upstream of the branch site may anchor U2 snRNP to pre-mRNA. SF3B1 may be involved in assembling the “E” complex.
Mentioned in ?
References in periodicals archive ?
H3B-8800 is an oral, potent and selective small molecule modulator of splicing factor 3b subunit 1 (SF3B1) that is being developed by H3 Biomedicine as an anticancer therapeutic agent.
[4] Human Genes: Gene symbol: SF3B1, Gene name: splicing factor 3B subunit 1.
Four of the most commonly mutated splicing factors are SF3B1 (splicing factor 3b subunit 1), SRSF2 (serine/arginine rich splicing factor 2), ZRSR2 (zinc finger RNA-binding motif and serine/arginine rich 2), and U2AF1 (U2 small nuclear RNA auxiliary factor 1, also known as U2AF35).

Full browser ?