Three of these segments use alternative splicing
to produce two essential viral proteins each, which are important in helping the virus gain entry into host cells.
refers to a process in which an RNA message copied from information encoded in a gene is edited before it is able to serve as a blueprint for the manufacture of a specific protein.
The Mesdan splicing
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The alternative splicing
is considered as a major mechanism for gene expression and function regulation and a source of protein diversity which resulted in expanding protein function repertoire in mammals (6-8).
To examine TLR5 alternative splicing
, THP-1 cells (1 x [10.sup.5] cells/ml) were treated with IFN-[gamma] (Invitrogen Corp.) for 0-24 h.
They believed that on one hand, steganography and splicing
had different goals and strategies causing different statistical artifacts on images, on the other hand, both of them made the touched (stego and spliced) image different from corresponding original ones.
Scientists at A*STAR's Genome Institute of Singapore (GIS), in collaboration with their counterparts from Canada, Hong Kong and the United States followed their previous study on a genome-wide investigation of gene functions in hESCs, and found that splicing
factors, such as the protein known as SON, are key regulators of hESC maintenance.
In our new study, it is clear that splicing
contributes to the unique cellular state of hESCs and this can be explained in part through the function of a protein known as SON.
In addition to skipping and inclusion of variable exons and usage of alternative splice sites,3 intron retention is a third example of alternative splicing
, whereby an intron sequence is retained or skipped in the mature mRNA transcript.4 Notwithstanding intron retention potentially affects mRNA transport to the cytoplasm5 and can insert a premature termination codon (PTC) and hence its degradation by the terminator (Non-sense mediate mRNA decay),6 there is an evidence for mRNAs that containing intron and are encoding biologically active proteins.4 The markedly increased alternative splicing
of genes in human cancers7,8 sheds the light on the possible pathways that might explain the exon containing PCT and whether they are sensitive or resistant to trigger the terminator.9
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An exon is a nucleic acid sequence that is represented in the mature form of an RNA molecule, either after portions of a precursor RNA (i.e., introns) has been removed by splicing
, or when two or more precursor RNA molecules have been ligated by splicing
Alternative pre-mRNA splicing
; theory and protocols.