spliceosome


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splic·e·o·some

(splīs'ē-ō-sōm'),
A specialized structure that participates in the removal of introns and resplicing of remaining exons of mRNA; in addition to the mRNA primary transcript, at least four small nuclear RNAs (snRNAs) and some proteins are involved.
[splice + -some]
Farlex Partner Medical Dictionary © Farlex 2012

spliceosome

(splīs′ə-sōm′)
n.
A nucleoprotein particle that aids in the splicing of messenger RNA in eukaryotes.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

spliceosome

molecular complex, including SMALL NUCLEAR RNAs/SMALL NUCLEAR RIBONUCLEOPROTEINS, essential to SPLICING.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
The spliceosome's job is to modify the message relayed from DNA by clipping genetic bits in such a manner that they are acceptable for translation into protein.
In the vertebrate nucleus, splicing is performed by the spliceosome, a ribosome-sized complex that contains mostly protein, but also includes, at various stages of the reaction, five snRNAs.
Then the lariat is joined by spliceosome and the introns are removed to form a circRNA.
Loss of immune tolerance to components of large RNP moieties being part of spliceosomes or ribosomes seems to be characteristic for distinct SARD [2].
Term KEGG pathway p value hsa05220 Chronic myeloid leukemia 0.004 hsa05215 Prostate cancer 0.008 hsa04810 Regulation of actin cytoskeleton 0.011 hsa05221 Acute myeloid leukemia 0.014 hsa04110 Cell cycle 0.024 hsa03040 Spliceosome 0.024 hsa05212 Pancreatic cancer 0.025 hsa04010 MAPK signaling pathway 0.029 hsa04350 TGF-beta signaling pathway 0.041
Spliceosome, a large ribonucleoprotein (RNP) complex that contains small nuclear RNP particles, snRNP, and other numerous protein factors including RNA helicases and protein kinases are involved in the splicing process in plants [21, 22].
Intron splicing accomplished by the spliceosome is closely related with four cis-acting elements, that is, the 5' splicing sites (5SS), the 3' splicing sites (3SS), the poly-pyrimidine tract (PPT), and the branch point (BP) [3].
Traditional models of how alternative splicing is regulated involve auxiliary splicing factors that bind to the premRNA and enhance or repress the ability of the spliceosome to recognize particular splice sites (20).
Vazquez, "The crosstalk between plant microRNA biogenesis factors and the spliceosome," Plant Signaling & Behavior, vol.
Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.