splice variant

splice variant

1. active mRNA that results from cutting and resealing or a RNA transcript by precise breakage of phosphodiester bonds at the 5' and 3' splice sites (exon-intron junction);
2. a recombinant DNA molecule derived from cutting and resealing of DNA from different sources.
References in periodicals archive ?
Impact of AR-V7 splice variant on treatment efficacy
The VEGF165 is secreted and binds to heparin, rendering it the most frequently studied splice variant.
An siRNA targeting the smaller splice variant consistently inhibited growth of MM6 cells.
RESULTS: Hydrocarbon challenge of metanephri from C57 mice altered Wilms' tumor suppressor gene (Wtl) mRNA splice variant ratios and reduced mRNAs of the Wtl transcriptional targets syndecan-1 (Sdcl) paired box gene 2 (Pax2), epidermal growth factor receptor (Egfr), and retinoic acid receptor, alpha {Hard).
Washington, May 31 (ANI): Scientists have pinpointed a small RNA that spurs cells to manufacture a particular splice variant of a key neuronal protein, potentially promoting Alzheimer's disease (AD) or other types of neurodegeneration.
The G589_A628 deletion in the AR protein was previously reported in breast cancer patients as due to an alternative splice variant of the AR gene (12).
CGEN-671 is a membrane splice variant of CD55, a known drug target for gastric cancer for which monoclonal antibody (mAb) therapeutics are in clinical development by others.
Other topics include the distribution of selenium and zinc, monocyte survival through defines intracellular pathways, insulin expression in rat testes and a new transcript splice variant of the human glacocorticoid receptor, while chemoprevention topics include the effects of wagonin, ginkgolide B, and phenolic phytochemicals.
ALT-110 is a therapeutic vaccine targeting EGFRvIII (pronounced "EGFR-v-3" for EGFR variant 3), a tumor-specific splice variant of the epidermal growth factor receptor (EGFR).
Each splice variant is then further annotated with information about homologues, SAGE-based expression profiles, open reading frames, sequence translation and detailed domain summaries.
They evaluated Wtl (Wilms' tumor suppressor gene) mRNA splice variant ratios and reduced mRNAs of the Wtl transcriprional targets Sdcl (syndecan-1), Pax2 (paired box gene 2), Egfr (epidermal growth factor receptor), and retinoic acid receptor, alpha (Rar [alpha]).
Finally, we found that a splice variant mRNA, KLK8-T4, may be an independent indicator of a poor prognosis for lung cancer patients.