The Oncotype DX AR-V7 Nucleus Detect liquid biopsy test was developed by Epic Sciences to help prolong the lives of men with metastatic castration-resistant prostate cancer (mCRPC) by accurately detecting a splice variant
of the androgen receptor protein (AR-V7) in the nucleus of circulating tumor cells.
analysis used the Human Splicing Finder .
The TF-A mRNA splice variant
is not translated to a protein (Fig.
The GNB3 splice variant
C825T (rs5443) is associated with risk for essential hypertension (EH) and efficacy of therapeutic drugs targeting GPCRs.
The trial is to compare galeterone to Xtandi (enzalutamide) in 148 mCRPC treatment-naive patients whose prostate tumours express the AR-V7 splice variant
Impact of AR-V7 splice variant
on treatment efficacy
The VEGF165 is secreted and binds to heparin, rendering it the most frequently studied splice variant
Smith and her colleagues discovered a splice variant
of the CCK-B receptor, known as the CCK-C receptor, which results from retention of the fourth intron on the CCK-B receptor and the insertion of 69 amino acids to the third intracellular loop, she explained.
An siRNA targeting the smaller splice variant
consistently inhibited growth of MM6 cells.
They evaluated Wtl (Wilms' tumor suppressor gene) mRNA splice variant
ratios and reduced mRNAs of the Wtl transcriprional targets Sdcl (syndecan-1), Pax2 (paired box gene 2), Egfr (epidermal growth factor receptor), and retinoic acid receptor, alpha (Rar [alpha]).
Washington, May 31 (ANI): Scientists have pinpointed a small RNA that spurs cells to manufacture a particular splice variant
of a key neuronal protein, potentially promoting Alzheimer's disease (AD) or other types of neurodegeneration.
vectensis is processed similarly to vertebrate usherin, with a small extracellular splice variant
in addition to a large transmembrane splice variant
(as supported but not proven by the RT-PCR results), then an important, phylogenetically conserved role for the form found in the extracellular matrix needs to be considered.