splice site


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splice site

The location on a strand of messenger RNA where the molecule can be cut and reannealed during the regulation of protein synthesis by cells.
See also: site
References in periodicals archive ?
SpliceMachine: predicting splice sites from high-dimensionallocal context representations" Bioinformatics 21:13321338 (2005)
Even if the RNA sequences are similar, splice site selections can vary and this would cause species variation.
The research, titled "Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition" is published in the latest issue of Cell.
On the other hand, the polymorphism in the polypyrimidine tract in the noncoding intron I near the 3' splice site of the INS (insulin) gene has been reported to affect pre-mRNA splicing and proinsulin secretion.
591C>T variant decreases the efficiency of, but does not abolish, the intron 9 donor splice site.
In this family, targeted next-generation sequencing combined with co-segregation analysis led to the identification of a novel DFNA5 mutation, IVS8+1 delG, which is located in the splice site of intron 8.
We used 90 arrays, each of which was capable of sequencing 27 048 bp (exons and splice sites, 11 477 bp).
These results showed that the mutation we report, for which we suggest the name Bartin, affects pre-mRNA maturation by inactivating the 5' splice site sequence at the 11th exon-intron boundary of the albumin gene, and is a previously unreported mutation causing analbuminemia.
html) predicted that the G[right arrow]A mutation would abolish splicing at the normal donor splice site of intron 9, and activate a cryptic donor site 40 by into the intron.
In conclusion, it seems that a suboptimal 5' splice site (donor site) and 3' splice site (branch point, pY tract, and acceptor site) play a major role in intron III retention of these genes.
The mutation occurs 23 positions downstream the 5' splice site in a tract that does not contain conserved sequence elements.