splice site


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splice site

The location on a strand of messenger RNA where the molecule can be cut and reannealed during the regulation of protein synthesis by cells.
See also: site
References in periodicals archive ?
A decrease of 100% suggests that the splice site is completely lost, thus incurring a frameshift resulting in the formation of truncated protein.
A feature is a sequence pattern with some functional significance such as start and stop codon splice sites and sequences that are recognized by protein in order to regulate gene expression [61].Several DNA features have been discovered and the list is still being populated as the research is going on.
3' Splice Site of Exon 7 Includes Enhancer for Exon 7 Inclusion of Both SMN2 and SMN1 Pre-mRNA.
However, the 5'ss hexanucleotides and especially the 3'ss hexanucleotides still exhibit a wide structural variability, confirming the contention that splicing depends on a complex code which, besides the 5'ss and 3'ss, possibly involves additional signals from the neighboring exons or from sections of the intron other than the splice sites and might also be regulated by the secondary and tertiary structures forming in the pre-mRNA molecule [12-14,16-23].
Section 3 introduces the basic knowledge about splice site and describes the method and process of our approach.
The c.578_579 + 5delAAGTATG [710_711 + 5del7] deletion that spans an exonic splice site causes a frameshift and could affect splicing at the same time.
Identification of a nonsense mutation producing a downstream cryptic 3' splice site. J Clin Invest 101:1028-1035.
The rivet system's tooling makes installation simpler and there is no need to supply compressed air to the splice site as was necessary with the previous system.
Based on the sequence characteristics of splice site, 0.28% to 0.52% of clean reads respectively in each individual were realigned to determine circRNAs (Table 2).
Cancer-associated SF3B1 hotspot mutations induce cryptic 3' splice site selection through use of a different branch point.
Fifty-seven different mutations (40 missense, 8 nonsense, 7 frameshift, 1 in-frame deletion, and one splice site) in GCK, 15 different mutations (11 missense, 3 frameshift, and one 3' UTR) in HNF1A and 4 different mutations (2 missense, one frameshift, and one indel) in HNF1B were found.
AS events are classified into several types: exon skipping, alternative 3' splice site (3'SS), alternative 5' splice site (5'SS), intron retention, mutually exclusive exons, alternative promoter, and poly(A).