splenomegaly


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splenomegaly

 [sple″no-meg´ah-le]
enlargement of the spleen.
congestive splenomegaly splenomegaly secondary to portal hypertension, with ascites, anemia, thrombocytopenia, leukopenia, and episodic hemorrhage from the intestinal tract. Called also Banti's disease.
hemolytic splenomegaly enlargement of the spleen associated with hemolytic diseases of the blood.
siderotic splenomegaly splenomegaly with deposit of iron and calcium.

sple·no·meg·a·ly

, splenomegalia (splē'nō-meg'ă-lē, -mĕ-gā'lē-ă),
Enlargement of the spleen.
Synonym(s): megalosplenia
[spleno- + G. megas (megal-), large]

splenomegaly

(splē′nō-mĕg′ə-lē, splĕn′ō-)
n. pl. splenomega·lies
Enlargement of the spleen.

splenomegaly

Enlarged spleen Enlargement of spleen for any reason, which is usually a manifestation of underlying disease; the only specific finding in splenomegaly is dragging sensation in the upper right quadrant; megalic spleens may reach 4.0+ kg–eg, in agnogenic myeloid metaplasia
Splenomegaly
Congestion Cirrhosis, CHF, thrombosis of portal or splenic veins
Infection
• Bacteria Brucellosis, infective carditis agents, syphilis, TB, typhoid fever
• Fungi Histoplasmosis
• Parasites Echinococcosis, leishmaniasis, malaria, schistosomiasis, toxoplasmosis, trypanosomiasis
• Viruses CMV, EBV
Inflammatory/immune-related Rheumatoid arthritis, SLE
Hematopoietic disease/Lymphoid function
• Malignant Leukemias, eg ALL, CLL, myeloproliferative disorders–eg agnogenic myeloid metaplasia, CML, multiple myeloma, polycythemia vera; lymphomas–Hodgkin's disease, NHL
• Nonmalignant Hemolytic anemia, histiocytosis, ITP
Storage diseases Gaucher's disease, mucopolysaccharidosis, Niemann-Pick disease
Etc Amyloidosis, cysts, hypersplenism, metastases, primary tumors

sple·no·meg·a·ly

, splenomegalia (splēnō-megă-lē, -mĕ-gālē-ă)
Enlargement of the spleen.
Synonym(s): megalosplenia.
[spleno- + G. megas (megal-), large]

splenomegaly

SPLEEN ENLARGEMENT.

Splenomegaly

Abnormal enlargement of the spleen. Splenomegaly is a major diagnostic criterion of PV.

sple·no·meg·a·ly

, splenomegalia (splēnō-megă-lē, -mĕ-gālē-ă)
Enlargement of the spleen.
[spleno- + G. megas (megal-), large]
References in periodicals archive ?
Predeparture or postarrival laboratory results were available for 84 of 85 refugees with documented splenomegaly and 24 of 32 without documented splenomegaly at their initial domestic exam (Table 2).
Refining the selection criteria for laparoscopic versus open splenectomy for splenomegaly. J Laparoendosc Adv Surg Tech A.
Neither the performed splenectomy nor the hematological investigation of our patient with previously known massive splenomegaly succeeded in determining the etiology of the splenomegaly and thrombocytopenia.
Isolated splenomegaly with systemic symptoms is unusual and clinically challenging.
Repeat CT imaging showed persistent gastric dilation and splenomegaly (Figure 3).
Fever and splenomegaly are hallmarks of Salmonella typhi infection, and hepatitis and cytopenias may be seen secondary to bone marrow suppression [6].
Ruxolitinib is found to relieve symptoms related to splenomegaly and is shown to reduce spleen size.
His physical examination was normal other than fever and rashes and splenomegaly on admission.
Clinico-hematological features might include thrombocytopenia, anemia, leucopenia, splenomegaly, and/or hepatomegaly (1).
Physical examination was significant for splenomegaly and mild tenderness at the left upper quadrant of the abdomen with no icterus, hepatomegaly, or lymphadenopathy.
Splenomegaly can also occur and these patients have an increased risk of traumatic splenic rupture [2].