Alexia without agraphia syndrome was first described by Dejerine in a patient who had a stroke in the medial part of the occipital lobe and the splenium of corpus callosum, impairing activation of orthographic word representations [1-3].
Magnetic resonance imaging indicated a lesion in the left medial temporal region, including the equilateral thalamus, posterior cingulate gyrus, splenium of corpus callosum, lingual occipital gyrus, and the tail of the hippocampus.
The vein of Galen is a short (1-2cm long), thick vein that passes posterosuperiorly behind the splenium of corpus callosum
in the quadrigeminal cistern.
Children who were admitted to the hospital from September 2015 to June 2017 with mild encepalitis/encephalopathy with complete recovery associated with MRI findings of a reversible lesion with transiently reduced diffusion isolated within the splenium of corpus callosum (SCC), within the SCC and subcortical frontoparietal, or involving the entire corpus callosum and subcortical frontoparietal white matter were reviewed from both radiology and pediatric neurology databases.
MRI findings of patients presenting with MERS Time to first MRI Time to follow-up after the onset Lesion type MRI after the onset Patient of symptoms (location, shape) of the symptoms 1 1 day I (SCC, ovoid) 37 days 2 2 days II (SCC and 42 days posterior periventricular white matter) 3 1 day I (SCC, ovoid) 10 days 4 1 day I (SCC, ovoid) 117 days 5 1 day I (SCC, ovoid) 21 days 6 1 day I (SCC, band) None 7 1 day I (SCC, ovoid) 21 days 8 1 day I (SCC, ovoid) 30 days Follow-up Patient MRI findings 1 CR 2 CR 3 CR 4 CR 5 CR 6 CR 7 CR 8 CR MERS, mild encephalopathy and reversible splenial lesion; MRI, magnetic resonance imaging; SCC, splenium of corpus callosum; CR, complete recovery.
Magnetic resonance imaging of the brain showed multiple areas with cytotoxic oedema in the bilateral frontal, occipital, temporal region (L > R), midbrain, pons, genu & splenium of corpus callosum
. A lumbar puncture revealed 0.5 mL of clear, colourless fluid without any cells, Glucose-80 mg/dL, and Protein-79 mg/dL.
Knyazeva, "Splenium of corpus callosum
: patterns of interhemispheric interaction in children and adults," Neural Plasticity, vol.
The corresponding comparison between FA indices showed significantly lower FA values in 2/8 regions (genu and splenium of corpus callosum
) in SPMS, 1/8 regions in both RRMS and PPMS (genu of corpus callosum), and 1/8 regions (caudate nucleus) in CIS (Figure 2(b)).
Global involutional changes, bilateral old lacunar infarcts and acute infarcts at splenium of corpus callosum
and deep white matter along the occipital horn of the right lateral ventricle were identified.