Diffusion-weighted imaging abnormalities in the splenium
The most notable significant clusters where FA was significantly lower in the FASD group than in the control group were in regions of the lateral splenium
of the CC (medial superior parietal white matter), posterior cingulate white matter bilaterally, and in the deep white matter of the right temporal lobe.
These authors used an ROI analysis and divided the corpus callosum into seven regions: rostrum, genu, rostral body, anterior midbody, posterior midbody, isthmus, and splenium
Aspirin did, however, appear to prevent age-related functional changes in the posterior cingulate and splenium
that were seen in those who did not take aspirin.
There is evidence, notes Witelson, that the splenium
largely transmits messages about sensory stimuli; the rest of the corpus callosum may be involved in higher-level processes that vary according to handedness.
In contrast, alexia without agraphia (which is associated with lesions to the left occipital lobe and the splenium
of the corpus callosum) was thought to arise from a disconnection of visual word form processing ( in the left angular gyrus) from visual processing in the occipital cortex.
Adrenolokodistrofinin klasik beyin MRG bulgularinda en sik gorme ve isitme yolaklarini icine alan, derin paryeto-oksipital beyaz cevher, korpus kallozum korpus posterior ve splenium
Results also implicate a specific neural circuit (the splenium
of the corpus callosum), which may develop differently in those at risk for ASD compared to typically developing infants, who show more rapid orienting to visual stimuli.
4 shows the various parameters successfully determined from the MS patient, plotted as a function of normalised distance along the CC midline, with the splenium
to the left and the genu to the right.
MRI of the brain showed large symmetric areas of restricted diffusion within the subcortical white matter, genu, splenium
of the corpus callosum, and minimally within the globus pallidi (Figures 1 and 2).
Transaxial FLAIR MR images (Figures 1A and 1B) demonstrate atrophy of skin and subcutaneous tissues overlying the left frontal calvarium (arrows), as well as ipsilateral cerebral atrophy and diffuse white matter hyperintensities involving the left frontal, parietal, and occipital lobes, external capsule, and corpus callosum splenium
Examination of HIV-infected individuals with DTI has revealed microstructural abnormalities of the genu and splenium
of the corpus callosum and frontal and parietal subcortical white matter related to disease severity (Filippi et al.