Drug-susceptibility testing demonstrated that levofloxacin and spiramycin
were effective on this strain.
Liu et al., "High concentrations of the antibiotic spiramycin
in wastewater lead to high abundance of ammonia-oxidizing archaea in nitrifying populations," Environmental Science & Technology, vol.
Several drugs have been proposed for treatment including pyrimethamine, sulfadiazine, spiramycin
, clindamycin, and trimethoprim-sulfamethoxazole .
Antibiotic Symbol [micro]g/ disc Clear zone diameter (mm) Ampicilin AM 10 08 R Streptomycin S 10 07 R Erythromycin E 15 15 R Kanamycin K 30 06 R Chloramphenicol C 30 22 S Pristinamycin PT 15 21 S Tobramycin TOB 10 09 R Clindamycin DA 2 23 S Spiramycin
SP 100 17 I Amikacin AK 30 12 R Licomycin L 2 25 S Cefotaxim CTX 30 00 R Nalidixique acid NA 30 00 R Gentamicin CN 10 08 R R: resistance, I: intermidiate, and S: sensitive.
Otto, "Erythromycin, carbomycin, and spiramycin
inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes," Antimicrobial Agents and Chemotherapy, vol.
The standard of lincomycin, from the lincosamides family, as well as the standards from the macrolides (clindamycin, erythromycin, spiramycin
, tilmicosin, and tylosin) and [beta]-lactams (cefazolin, cloxacillin, dicloxacillin, oxacillin, nafcillin, penicillin G, and penicillin V) families were purchased from Sigma Chemical Co.
(vi) Preparation of the antibiotic paste: 1.5 MIU Spiramycin
pill and 250 mg Metronidazole were ground and mixed with distilled water (Figure 2).
Based on the inhibitory effect on the microbes in vitro of the 6 antimicrobial agents (including erythromycin, roxithromycin, azithromycin, acetyl spiramycin
, clindamycin, and clarithromycin, at high and low concentrations) in the drug sensitivity plate, the microbial drug resistance was analyzed.
Brumpt, Simultaneous Determination of Metronidazole and Spiramycin
I in Human Plasma, Saliva and Gingival Crevicular Fluid by LC-MS/MS, J Pharm Biomed Anal., 38, 298 (2005).
In vitro susceptibilities of oral bacteria isolate to spiramycin
. Antimicrob Agents Chemothe, 1989; 33(11): 2016-2018
Minimal inhibitory concentrations of Pasteurella multocida was investigated and found highly resistant for spiramycin
and fosfomycin .