The most frequent diseases considered in the differential diagnosis were ulcers caused by trauma, spinocellular
carcinoma, and autoimmune diseases.
Motran cited the most spread kinds of skin cancer as follows: Basal cell carcinoma (BCC), spinocellular
carcinoma, and melanoma.
Lymphocytes are the main IL-2 producers, however in normal tissues, and several tumours, including stomach, renal and spinocellular
cancer and squamous cell carcinomas of the head and neck, IL-2 seems to be present and stimulate cell proliferation (22, 23).
A 52-year-old woman with a medical history of depression, alcohol and nicotine abuse developed an invasive spinocellular
epithelioma of the lower oesophagus.
The differential diagnosis of donovanosis should be done with primary syphilis and some secondary forms (such as condyloma), Ducrey's diseases (principally in its phagedenic form or with a cluster of papules), chronic herpes ulcers, condyloma acuminata (most importantly when large and in a common area), lymphogranuloma (when donovanosis is inguinal and elephantiastic) and spinocellular