(15) The dove in this report had a spindle cell sarcoma
mass identified 8 months after the initial diagnosis of osteosarcoma.
The histology was consistent with a low grade spindle cell sarcoma
, and, as such, no chemotherapy was recommended at that point in time.
Caption: Figure 4: H&E x40 showing spindle cell sarcoma
with hemangiopericytic pattern.
(1,2) Sarcomas of the elderly are leiomyosarcoma, angiosarcoma, spindle cell sarcoma
, alveolar soft part sarcoma, fibrosarcoma, neurofibrosarcoma, and mixed mesodermal tumors of the vagina.
Ultra-sound guided biopsy was subsequently conducted which indicated the lesion was a high-grade spindle cell sarcoma
. There was no evidence of metastases or further bony lesions on CT scanning of the chest and whole body isotope bone scan.
Hence, a guarded FNACBP diagnosis of spindle cell sarcoma
(2,23,24) The dedifferentiated area can be conventional high-grade osteosarcoma with various subtypes (osteoblastic, fibroblastic, chondroblastic, giant cell rich, and telangiectatic) or pleomorphic spindle cell sarcoma
. (2,23,25) Evidence shows that dedifferentiated parosteal osteosarcoma has the same distinct amplification of the CDK4 and MDM2 genes (Figure 3, B).
Some malignant cases demonstrate a histologically typical, benign-appearing, solitary fibrous tumor component with an abrupt transition to a high-grade spindle cell sarcoma
When there is a lack of S100 protein expression and a broad panel of immunostains, including cytokeratin, EMA, and SMA, yields only focal or equivocal staining, PGP9.5 is a useful marker in confirming the neural origin of a spindle cell sarcoma
. Table 1.
The coexistence of neuroendocrine carcinoma and spindle cell sarcoma
in the esophagus is extremely rare.
Radical subtotal gastrectomy was performed, based on the pathologic diagnosis of spindle cell sarcoma
from gastroscopic biopsy specimens.
Distinct areas of rhabdomyosarcoma, liposarcoma, and spindle cell sarcoma
with features of malignant pheripheral nerve sheath tumor were indentified (figure 2, a through d).