spindle cell carcinoma


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Related to spindle cell carcinoma: spindle cell sarcoma

carcinoma

 [kahr″sĭ-no´mah] (pl. carcinomas, carcino´mata)
a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue.
adenocystic carcinoma (adenoid cystic carcinoma) carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. Called also cylindroma.
alveolar carcinoma bronchioloalveolar carcinoma.
basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells, rarely metastatic but locally invasive and aggressive. It usually occurs as small pearly nodules or plaques on the face of an older adult, particularly on a sun-exposed area of someone with fair skin. It has been divided into numerous subtypes on the basis of clinical and histological characteristics.
basosquamous carcinoma carcinoma that histologically exhibits both basal and squamous elements.
bronchioalveolar carcinoma (bronchiolar carcinoma) (bronchioloalveolar carcinoma) (bronchoalveolar carcinoma) a variant type of adenocarcinoma of the lung, with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. Called also alveolar carcinoma or adenocarcinoma and bronchiolar, bronchioloalveolar, or bronchoalveolar adenocarcinoma.
bronchogenic carcinoma any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.
cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles, consisting of two layers of cells surrounding a minute lumen. Called also bile duct carcinoma and cholangiocarcinoma.
chorionic carcinoma choriocarcinoma.
colloid carcinoma mucinous carcinoma.
cylindrical cell carcinoma carcinoma in which the cells are cylindrical or nearly so.
embryonal carcinoma a highly malignant germ cell tumor that is a primitive form of carcinoma, probably of primitive embryonal cell derivation; it usually arises in a gonad and may be found either in pure form or as part of a mixed germ cell tumor.
epidermoid carcinoma squamous cell carcinoma.
giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs.
hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. It is rare in North America and Western Europe but is one of the most common malignancies in parts of sub-Saharan Africa, Southeast Asia, East Asia, and elsewhere. A strong association seems to exist with chronic hepatitis B virus infection.
Hürthle cell carcinoma a malignant Hürthle cell tumor.
carcinoma in si´tu a neoplasm whose tumor cells are confined to the epithelium of origin, without invasion of the basement membrane; the likelihood of subsequent invasive growth is presumed to be high.
large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation.
medullary carcinoma that composed mainly of epithelial elements with little or no stroma.
mucinous carcinoma an adenocarcinoma that produces significant amounts of mucin.
nasopharyngeal carcinoma a malignant tumor arising in the epithelial lining of the nasopharynx, occurring at high frequency in people of Chinese descent. The epstein-barr virus has been implicated as a causative agent.
non–small cell carcinoma a general term comprising all lung carcinomas except small cell carcinoma, and including adenocarcinoma of the lung, large cell carcinoma, and squamous cell carcinoma.
oat cell carcinoma a form of small cell carcinoma in which the cells are round or elongated and slightly larger than lymphocytes; they have scanty cytoplasm and clump poorly.
papillary carcinoma carcinoma in which there are papillary growths that are irregular in nature arising from otherwise normal tissue; it can occur in the thyroid gland, the breast, or the bladder. Called also papillocarcinoma.
renal cell carcinoma carcinoma of the renal parenchyma, composed of tubular cells in varying arrangements; called also clear cell carcinoma.
scirrhous carcinoma carcinoma with a hard structure owing to the formation of dense connective tissue in the stroma. Called also fibrocarcinoma.
carcinoma sim´plex an undifferentiated carcinoma.
small cell carcinoma a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells. Metastasis to the hilum and to mediastinal lymph nodes is common.
spindle cell carcinoma squamous cell carcinoma marked by development of rapidly proliferating spindle cells.
squamous cell carcinoma
1. carcinoma developed from squamous epithelium, having cuboid cells and characterized by keratinization. Initially local and superficial, the lesion may later invade and metastasize.
2. the form occurring in the skin, usually originating in sun-damaged areas or preexisting lesions.
3. in the lung, one of the most common types of bronchogenic carcinoma, generally forming polypoid or sessile masses that obstruct the airways of the bronchi. It usually occurs in middle-aged individuals with a history of smoking. There is frequent invasion of blood and lymphatic vessels with metastasis to regional lymph nodes and other sites. Called also epidermoid carcinoma.
transitional cell carcinoma a malignant tumor arising from a transitional type of stratified epithelium, usually affecting the urinary bladder.
verrucous carcinoma
1. a variety of squamous cell carcinoma that has a predilection for the buccal mucosa but also affects other oral soft tissue and the larynx. It is slow-growing and somewhat invasive.
2. Buschke-Löwenstein tumor, so called because it is histologically similar to the oral lesion.

spin·dle cell car·ci·no·ma

a carcinoma composed of elongated cells, frequently a poorly differentiated squamous cell carcinoma that may be difficult to distinguish from a sarcoma.

spindle cell carcinoma

A carcinoma—often squamous cell—which can occur on any epithelial surface (e.g., oral, anorectal, bladder, etc). The cells are spindled, simulate a sarcoma (but stain for cytokeratin), and usually are more aggressive than non-spindle cell carcinomas.

spindle cell carcinoma

Carcinosarcoma, pseudosarcoma An aggressive and poorly differentiated carcinoma composed of sweeping fascicles of elongated epithelial cells of transitional, squamous, undifferentiated or rarely glandular origin that mimics a sarcoma clinically and pathologically; SCCs are most common in the oral cavity–♂:♀ ratio, 10:1, and a variant of squamous cell carcinoma; it also occurs in the larynx, upper respiratory and upper GI tracts, thyroid gland, breast, rarely in the female genital tract;14 of Pts with SCC have had regional RT Treatment Surgery

spin·dle cell car·ci·no·ma

(spin'dĕl sel kahr'si-nō'mă)
A carcinoma composed of elongated cells, frequently a poorly differentiated squamous cell carcinoma that may be difficult to distinguish from a sarcoma.
References in periodicals archive ?
Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases.
Chen, "Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome," Journal of the Chinese Medical Association, vol.
Mucinous tubular and spindle cell carcinoma. In: Eble J, Sauter G, Epstein J, Sesterhenn I (eds).
There were 8 cases of metastatic melanoma, 7 of metastatic spindle cell carcinoma and 2 unclassified malignant neoplasms (Table 2).
Both signet ring cell carcinoma and spindle cell carcinoma were N2 in 100% of their cases; 11.1% cases of Mucinous carcinoma were presented with metastasis at the time of diagnosis whereas only 4.7% cases of Adenocarcinoma NOS had evidence of metastasis.
Low grade fibromatosis-like spindle cell carcinoma is a variant of SCMC characterised by at least 95% of the tumour consisting of bland spindle cells [12,13].
Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare subtype of renal cell carcinoma (RCC), which was first recognized as a distinct entity in the 2004 World Health Organization (WHO) tumour classification as well as in the newly revised 4th edition published in 2016 [1].
(2) Primary histopathologic differential diagnostic considerations include angiofibroma, fibrous histiocytoma, spindle cell carcinoma, spindle cell melanoma, fibromatosis, fibrosarcoma and fibroosseous lesion such as ossifying fibroma.
Malignant phylloides tumours must be distinguished from spindle cell carcinoma, primary breast sarcoma & metastasis of sarcoma to breast.
Immunohistochemical and ultra-structural studies support this theory.[8] Wick and Swanson favor the term sarcomatoid carcinoma for these complex neoplasms, but carcinosarcoma and spindle cell carcinoma continue to appear in the literature and remain commonly accepted terms.[8]