In conclusion, this report presents a unique case of a patient who manifested both phenotypes of the gain- and loss-of-function mutations of KCNMA1 (dyskinesia, epilepsy, and cerebellar atrophy) and had tegmental and spinal tract
atrophy that has not been reported to date.
Those signals descend from the cortex to the spinal tract
, speeding through the spine while jumping to other motor neurons that then excite muscle fibers.
Fifty-five (55%) of total cervical movement (most prominently rotation) is provided by the atlanto-axial joint (C1-C2), which houses the trigeminal spinal tract subnucleus and C1-C2 dorsal horns.
Such a mechanism could also be used to explain a TMJ dysfunction brought on by swimming via relay through the previously mentioned trigeminal spinal tract subnucleus and C1-C2 dorsal horn transitional zone.
Using this approach, we were able to verify whether forelimb motor function recovered on the injured side not only after damage to the cerebral cortex spinal tract
, but also after injury to the cervical spinal cord via the route change of the corticospinal tract on the uninjured side.
Therefore, continued investigation of the exact spinal tracts
and systems involved and nature of the circuit rewiring is of the utmost importance to understand the full complexity of the mechanisms of recovery.
IMAGING FINDINGS: Axial T2 FLAIR image reveals a symmetric hyperintensity involving the central pontine region, sparing the tegmentum and cortico spinal tracts resulting in a characteristic Mexican hat or bat wing configuration of hyperintensity.
Figure 1: Axial T2 FLAIR image demonstrates a symmetric hyperintensity involving the central pontine region, sparing the tegmentum and cortico spinal tracts resulting in a characteristic Mexican hat or bat wing configuration of hyperintensity.
At the spinal cord, the pain stimulus enters the cord and travels along specified "sensory spinal tracts
" to the brain.
These spinal tracts
transmit information between the brain and body.
Collectively, these animal studies indicate some spinal tracts
undergo a fair amount of spontaneous sprouting, providing new neuronal pathways that could be targeted for increasing growth, regeneration, and functional recovery of movements and sensations.