He proposed that spike and wave paroxysms as EEG substrate of absences emerge from the same circuit that normally produces sleep spindles and the former are epileptic transformation of sleep spindles.
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Charpier, "Activity of thalamic reticular neurons during spontaneous genetically determined spike and wave discharges," Journal of Neuroscience, vol.
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A new model of petit mal epilepsy: spontaneous spike and wave
discharges in the tremor rats.
Intermittent photic stimulation precipitated spike and wave
pattern in 8 patients (13.3%) more so in females than males (6 females2 males).
In 3%, hyperventilation procedures precipitated abnormality in the form of spike and wave 3HZ/sec.
Table--8 Showing the types of Abnormalities in EEG : TYPES OF ABNORMALITY NUMBER SPECIFIC: Spike and Wave 31 (73.8%) Spike 3 (7.1%) Sharp wave 1 (2.4% Sharp wave & slow wave 1 (2.4% NON SPECIFIC: Slow wave 6 (14.3%) TOTAL 42 Out of the total number of 100 records, 42 demonstrated an abnormality in the EEG.
Among the generalized EEG abnormalities (33 records), majority (87.9%) showed a generalized spike and wave discharge which were bilateral symmetrical and synchronous.
In this study, all the 3 children who had hyperventilation documented 3 Hz spike and wave activity confirming the diagnosis (Table 6).