S1PR1

(redirected from sphingosine-1-phosphate receptor 1)

S1PR1

A gene on chromosome 1p21 that encodes an EDG (endothelial differentiation, G protein-coupled) family receptor, which is highly expressed in endothelial cells. It binds the sphingosine-1-phosphate with high affinity and high specificity, and may be involved in regulating endothelial cell differentiation. Receptor activation induces cell–cell adhesion.
Mentioned in ?
References in periodicals archive ?
2014) Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo.
Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration.
As a result, five genes were determined as putative targets of recent artificial selection as follows: diphthine synthase 5 (DPH5), sphingosine-1-phosphate receptor 1 (S1PR1), olfactomedin 3 (OLFM3), leucine-rich repeat neuronal protein 1 (LRRN1) and protein cereblon (CRBN).
The company said that the capital will support its lead sphingosine-1-phosphate receptor 1 (S1P1) clinical candidate through Phase I human clinical trials, development of a second IND candidate, as well as the select partnering of the proprietary technology platform for GPCR drug discovery and development.