sphingosine


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Related to sphingosine: cerebroside, ceramide, sphingomyelin

sphingosine

 [sfing´go-sēn]
a basic amino alcohol present in sphingomyelin.

sphin·go·sine

(sfing'gō-sēn),
The principal long-chain base found in sphingolipids.
Synonym(s): , sphingol

sphingosine

(sfĭng′gə-sēn′)
n.
A basic, long-chain, unsaturated amino alcohol, C18H37NO2, that combines with lipids to form sphingolipids.

sphin·go·sine

(sfing'gō-sēn)
The principal long-chain base found in sphingolipids.
References in periodicals archive ?
Pitson, "Regulation of sphingosine kinase and sphingolipid signaling," Trends in Biochemical Sciences, vol.
These data suggest that compound X is indeed a lysoGb3 with a sphingosine base containing 1 additional double bond, consistent with the findings of Auray-Blais and colleagues (8).
LPS activate the SK1/S1P signalling axis in several cell types including mouse macrophages [85] leading to translocation of SK1 to the plasma membrane where it converts its substrate sphingosine to S1P.
After the equine epidemic of moldy corn disease, Riley observed that fumonisin B, closely resembles several sphingolipids, including sphingosine. He and Merrill tested the toxin to see if it also affected PKC.
Sph generated by the ceramidases can be phosphorylated to S1P by sphingosine kinase (SphK) [12].
It targets a different part of the same cell signaling pathway, the "sphingosine pathway," also targeted by Enzo's proprietary sphingosine kinase inhibitor, SK1-I, which Enzo is currently developing for the treatment of HCC.
According to the company, Mayzent is a next generation, selective sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (RMS).
S6 students Aleena Nauman and Nicola Li have been announced as one of the winners of The Big Bang online heats, with their project entitled 'Fibroblast Secreted Factors Activate Components of the Sphingosine Kinase Pathway in Acute Myeloid Leukemic Cells'.
-- The Hamdan Award for Original Research Paper Published in the Hamdan Medical Journal: Sehamuddin Galadari & Siraj Pallichankandy, Anees Rahman, Faisal Thayyullathil for their paper 'Sphingosine analogue FTY720 sensitises arsenic trioxide-induced autophagic cell death in human malignant glioma cells.'
The new facility will enhance space for GMP production of the company's development-stage clinical candidates, including Enzo's proprietary sphingosine kinase 1 inhibitor, SK1-I, which is being investigated for potential applications in oncology and autoimmune diseases.
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro .
The inhibitor, ABC294640, acts in a way that prevents cancer cells from protecting their telomeres, by inhibiting an enzyme called sphingosine kinase 2.

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