Pitson, "Regulation of sphingosine
kinase and sphingolipid signaling," Trends in Biochemical Sciences, vol.
These data suggest that compound X is indeed a lysoGb3 with a sphingosine
base containing 1 additional double bond, consistent with the findings of Auray-Blais and colleagues (8).
LPS activate the SK1/S1P signalling axis in several cell types including mouse macrophages  leading to translocation of SK1 to the plasma membrane where it converts its substrate sphingosine
After the equine epidemic of moldy corn disease, Riley observed that fumonisin B, closely resembles several sphingolipids, including sphingosine
. He and Merrill tested the toxin to see if it also affected PKC.
Sph generated by the ceramidases can be phosphorylated to S1P by sphingosine
kinase (SphK) .
It targets a different part of the same cell signaling pathway, the "sphingosine
pathway," also targeted by Enzo's proprietary sphingosine
kinase inhibitor, SK1-I, which Enzo is currently developing for the treatment of HCC.
According to the company, Mayzent is a next generation, selective sphingosine
1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (RMS).
S6 students Aleena Nauman and Nicola Li have been announced as one of the winners of The Big Bang online heats, with their project entitled 'Fibroblast Secreted Factors Activate Components of the Sphingosine
Kinase Pathway in Acute Myeloid Leukemic Cells'.
-- The Hamdan Award for Original Research Paper Published in the Hamdan Medical Journal: Sehamuddin Galadari & Siraj Pallichankandy, Anees Rahman, Faisal Thayyullathil for their paper 'Sphingosine
analogue FTY720 sensitises arsenic trioxide-induced autophagic cell death in human malignant glioma cells.'
The new facility will enhance space for GMP production of the company's development-stage clinical candidates, including Enzo's proprietary sphingosine
kinase 1 inhibitor, SK1-I, which is being investigated for potential applications in oncology and autoimmune diseases.
Role of sphingosine
kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro .
The inhibitor, ABC294640, acts in a way that prevents cancer cells from protecting their telomeres, by inhibiting an enzyme called sphingosine