ABCA1 transports phosphatidylcholine, phosphatidylinositol (4,5) bis-phosphate (PIP2) , and less efficiently phosphatidylserine and sphingomyelin .
HCBS mainly consists of phosphatidylcholine, and not sphingomyelin, and is not associated with caveolin-1.
Interestingly, ABCG1, in addition to cholesterol, transports sphingomyelin, and different structural motifs are responsible for binding of these lipids.
Steck, "Plasma membranes contain half the phospholipid and 90% of the cholesterol and sphingomyelin in cultured human fibroblasts," The Journal of Biological Chemistry, vol.
Jiang et al., "Association of plasma sphingomyelin
levels and incident coronary heart disease events in an adult population multi-ethnic study of atherosclerosis," Arteriosclerosis Thrombosis and Vascular Biology, vol.
In order to simultaneously characterize lipids and polar metabolites with different intensity, a novel liquid-liquid extraction method was developed to extract and separate them from one micro amount of sample (100 [micro]l) and then sphingolipids was analyzed on triple quadrupole LC-MS; phosphoglycerides, glycerides and sphingomyelins
were analyzed on high resolution LC-MS: and polar metabolites were determined on another triple quadrupole LC-MS.
Holthuis, "Identification of a family of animal sphingomyelin synthases," The EMBO Journal, vol.
CL = free cholesterol; lyso-PC = lysophosphatidylcholine; PC = phosphatidylcholine; SM = sphingomyelin.
Ceramides can be produced by de novo synthesis, sphingomyelin
catabolism or on salvage pathway .
It is possible, she said, that if a sphingomyelinase inhibitor were used to slow down the process of breaking down sphingomyelins
into ceramides, the progression of the disease could be interrupted.
 Nonstandard abbreviations: HF, heart failure; NT-proBNP, N-terminal pro-B-type natriuretic peptide; HFrEF, heart failure with reduced ejection fraction; ICMP, ischemic cardiomyopathy; NICMP, nonischemic cardiomyopathy; NYHA, New York Heart Association; cMRI, cardiac MRI; LVEF, left ventricular ejection fraction; PCA, principal component analysis; BMI, body mass index; AUC, area under the curve; AIC, Akaike information criterion; BIC, Bayesian information criterion; SM, sphingomyelin
; TAG, triglyceride; PC, phosphatidylcholine; CE, cholesterylester; CAD, coronary artery disease; ACE, angiotensin-converting enzyme.