sphingomyelin phosphodiesterase


Also found in: Wikipedia.

sphin·go·my·e·lin phos·pho·di·es·ter·ase

(sfing'gō-mī'ĕ-lin fos'fō-dī-es'tĕr-ās),
An enzyme catalyzing hydrolysis of sphingomyelin to N-acylsphingosine (a ceramide) and phosphocholine; a deficiency of this enzyme is associated with type I Niemann-Pick disease.
Synonym(s): sphingomyelinase
Farlex Partner Medical Dictionary © Farlex 2012

sphin·go·my·e·lin phos·pho·di·es·ter·ase

(sfing'gō-mī'ĕ-lin fos'fō-dī-es'tĕr-ās)
An enzyme catalyzing hydrolysis of sphingomyelin to N-acylsphingosine (a ceramide) and phosphocholine; a deficiency of this enzyme is associated with type I Niemann-Pick disease.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Analysis of the sphingomyelin phosphodiesterase 1 gene (SMPD1) in Turkish Niemann-Pick disease patients: mutation profile and description of a novel mutation.
Hannun, "Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MAnSMase), the mammalian sphingomyelin phosphodiesterase 5," The Journal of Biological Chemistry, vol.
Increasing studies demonstrate that neutral sphingomyelinase (nSMase), also known as sphingomyelin phosphodiesterase, an enzyme that uses sphingomyelin (SM) as a substrate to produce ceramide and phosphocholine, may regulate many cell physiopathology processes [12].
The expression of the following enzymes was investigated: ceramide synthase 2 (CerS2), ceramide synthase 4 (CerS4), fatty acid elongase 1 (ELOVL1), fatty acid elongase 3 (ELOVL3), alkaline ceramidase 2 (ACER2), serine palmitoyltransferase, long chain base subunit 2 (SPTLC2), sphingomyelin phosphodiesterase 1 acid lysosomal (SMPD1), and stearoyl-CoA desaturase (delta-9-desaturase, SCD1).
Regeneration of ceramide from sphingomyelin is carried out by the plasma membrane bound enzyme SMPD (sphingomyelin phosphodiesterase) as presented in Figure 2.