Four novel p.N385K, p.V36A, c.1033-1034insT and c.1417-1418delCT mutations in the sphingomyelin
Phosphodiesterase 1 (SMPD1) gene in patients with types A and B Niemann-Pick disease (NPD).
Koo, "Milk sphingomyelin
is more effective than egg sphingomyelin
in inhibiting intestinal absorption of cholesterol and fat in rats," Journal of Nutrition, vol.
Two major pathways, sphingomyelin
hydrolysis and de novo biosynthesis, have been implicated in the generation of ceramide.
Abbreviations a-SMase: Acid sphingomyelinase alk-SMase: Alkaline sphingomyelinase C1P: Ceramide 1-phosphate Cer: Ceramide CerK: Ceramide kinase CerS: Ceramide synthases CPTP: Ceramide-1-phosphate transfer protein DAG: Diacylglycerol GluCer-synthase: Glucosylceramide synthase GluCer: Glucosylceramide LacCer-synthase: Lactosylceramide synthase LacCer: Lactosylceramide LynK: Lyn kinase n-SMase: Neutral sphingomyelinase PAMPs: Pathogen-associated molecular patterns PC: Phosphatidylcholine PPC: Phosphorylcholine PRRs: Pattern recognition receptors RSM-synthase: Reverse sphingomyelin
synthase S1P: Sphingosine- 1-phosphate S1PL: S1P lyase SM: Sphingomyelin
SM: Synthase SMase: Sphingomyelinase Sph: Sphingosine SphK: Sphingosine kinase SphPh: Sphingosine phosphatase.
Jiang et al., "Association of plasma sphingomyelin
levels and incident coronary heart disease events in an adult population multi-ethnic study of atherosclerosis," Arteriosclerosis Thrombosis and Vascular Biology, vol.
is the most abundant of the 7 types of sphingolipids, constituting approximately 5-6 mol % of total lipids.
Slotte, "Interaction of cholesterol with synthetic sphingomyelin
derivatives in mixed monolayers," Biochemistry, vol.
The mammalian T-tubule membranes are highly enriched in sphingomyelin
and cholesterol compared to the surface sarcolemma .
According to the authors, this increase in red cell rigidity might be due to enhanced sphingomyelin
By means of UPLC/MS technology, we found in a previous study that there are significant changes between the phospholipid levels of AMI patients before I/R treatment compared to healthy controls – specifically, glycerophospholipid is significantly down-regulated and most sphingomyelin
are up-regulated.[sup] We found similar changes in phospholipid metabolic pathways after emergency reperfusion therapy in the infarction zone of youth STEMI patients, in accordance with our previously published results; moreover, as discussed above, sphingolipid metabolism was the top most altered metabolic factor.
Along with an increase in maintenance of total phospholipids (TP) (P < 0.01), fractions of lysophosphatidylcholine (LPC), phosphatidylserine (PS), phosphatidylethanolamine (PEA) (P < 0.05) raise and the maintenance of fractions sphingomyelin
(SPM) (P < 0.01), phosphatidylcholine (PC) (P < 0.01) decreases that lead to an increase in a value of the coefficient saying of a relation between easily oxidizable (PS, PEA) to difficult oxidizable (SPM, PC).
Phosphatidilcholine and sphingomyelin
profiles vary in Bos taurus x indicus and Bos taurus x taurus in vitro and in vivo-produced blastocysts.