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1. A small spheric structure.
2. A sporangiallike structure filled with endospores at maturity, produced within tissue and in vitro by Coccidioides immitis.
[LL. sphaerula, dim. of L. sphaera, sphere, ball]
Farlex Partner Medical Dictionary © Farlex 2012


A thick-walled, nonbudding structure recognized as the tissue form of Coccidioides immitis; variable in size, it may contain endospores or granular material. When the spherule ruptures, it releases endospores into the surrounding tissues.
[LL. sphaerula, dim. of L. sphaera, sphere, ball]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


a thick-walled structure containing large numbers of fungal spores.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
to germinate into spherules at 37[degrees]C and for optional growth of Histoplasma capsulatum yeast [15, 16].
Moreover, industrial spherules may contaminate the natural glasses, both at the outcrop and during laboratory treatments [3-5].
Since in all the above-mentioned mires silicate spherules were detected only in one layer, we proposed a new precise correlation method for Holocene sequences, based on these microimpactites.
Chemical analyses of the South African sediments show that, on average, the layers that contain the spherules have more than 10 times the concentration of iridium that's normally found in Earth's crust, as well as elevated concentrations of certain chromium isotopes.
(1,38) Both are caused by fungi that grow as spore producing hyphae at environmental temperatures, but as yeasts (spherules or ellipses) at body temperature within the lungs.
The most common form of C immitis seen in biological specimens is variably sized (20-200 pm), thick-walled mature spherules containing numerous endospores ranging from 2 to 5 [micro]m (Figure 16).
Inagaki, Formation of carbon spherules by pressure carbonization-Relation to molecular structure of precursor, Carbon, 26, 303 (1988).
Histopathology examination revealed that the abscess was pyogranulomatous, with visible fungal spherules morphologically consistent with Coccidioides spp.
The pathology report also confirmed to be positive for Coccidioides spherules (Figures 1 and 2).
The agents used for this purpose are as follows: sclerosing agents (Fibrin glue, Tetrasycline, Hidrocloric acide, Microporous Polysaccharide spherules, Iodized talc), anti-inflammatory drugs (Acetyl salicylic acid, Nonsteroidal anti-inflammatory drugs), chemotherapeutic agents (Fluorouracil, Mytomycin-C) and radiotherapy.