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1. A small spheric structure.
2. A sporangiallike structure filled with endospores at maturity, produced within tissue and in vitro by Coccidioides immitis.
[LL. sphaerula, dim. of L. sphaera, sphere, ball]


A thick-walled, nonbudding structure recognized as the tissue form of Coccidioides immitis; variable in size, it may contain endospores or granular material. When the spherule ruptures, it releases endospores into the surrounding tissues.
[LL. sphaerula, dim. of L. sphaera, sphere, ball]


a thick-walled structure containing large numbers of fungal spores.
References in periodicals archive ?
to germinate into spherules at 37[degrees]C and for optional growth of Histoplasma capsulatum yeast [15, 16].
Direct examination: Direct microscopical examination of the secretions (alveolar aspirate, cerebrospinal fluid, exudate) stained with calcofluor-white (which joins the chitin or cellulose of the cell wall) and observed in a fluorescence microscope, allow the visualizing the spherules with a 22% sensitivity.
The results were interpreted as indicating the presence of spherical fine-grained (~ 4-5 nm) magnetite particles, suggested to come from weathered glass spherules produced by the Chicxulub impact.
Moreover, industrial spherules may contaminate the natural glasses, both at the outcrop and during laboratory treatments [3-5].
Since in all the above-mentioned mires silicate spherules were detected only in one layer, we proposed a new precise correlation method for Holocene sequences, based on these microimpactites.
Chemical analyses of the South African sediments show that, on average, the layers that contain the spherules have more than 10 times the concentration of iridium that's normally found in Earth's crust, as well as elevated concentrations of certain chromium isotopes.
(1,38) Both are caused by fungi that grow as spore producing hyphae at environmental temperatures, but as yeasts (spherules or ellipses) at body temperature within the lungs.
The most common form of C immitis seen in biological specimens is variably sized (20-200 pm), thick-walled mature spherules containing numerous endospores ranging from 2 to 5 [micro]m (Figure 16).
Inagaki, Formation of carbon spherules by pressure carbonization-Relation to molecular structure of precursor, Carbon, 26, 303 (1988).
Histopathology examination revealed that the abscess was pyogranulomatous, with visible fungal spherules morphologically consistent with Coccidioides spp.
The pathology report also confirmed to be positive for Coccidioides spherules (Figures 1 and 2).
The agents used for this purpose are as follows: sclerosing agents (Fibrin glue, Tetrasycline, Hidrocloric acide, Microporous Polysaccharide spherules, Iodized talc), anti-inflammatory drugs (Acetyl salicylic acid, Nonsteroidal anti-inflammatory drugs), chemotherapeutic agents (Fluorouracil, Mytomycin-C) and radiotherapy.