Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine
oxidase," Oncogene, vol.
, an anti-oxidant found in semen that's said to get rid of wrinkles and smoothen out the skin.
and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase.
These polyamines, including spermine
and spermidine, have been shown to accumulate in the synovium and urine of patients with rheumatoid arthritis.
Nondestructive quantitation of spermine
in human prostate tissue samples using HRMAS 1H NMR spectroscopy at 9.
Groppa MD, Tomaro ML, Benavides MP (2007) Polyamines and heavy metal stress: the antioxidant behavior of spermine
in cadmium-and copper-treated wheat leaves.
2010, Genetic and epigenetic influences on expression of spermine
synthase and spermine
oxidase in suicide completers, International Journal of Neuropsychopharmacology, 13, 6, 725-736.
Functional K(ATP) channels in the rat retinal microvasculature: topographical distribution, redox regulation, spermine
modulation and diabetic alteration.
Putrescine is converted to spermidine and spermine
with the help of SAMe, and these two polyamines then act in the cell to influence gene expression, cell proliferation and growth, the flow of calcium and the production of yet other regulators.
Amdl (Adenosyl methionine decarboxylase) is required for the synthesis of the polyamines spermine
72) In another study, (73) in a series of 14 differentially expressed genes, 8 were upregulated: CFB (complement factor B), FTL (ferritin, light polypeptide), IGFBP7 (insulin-like growth factor-binding protein 7), RARRES1 (retinoic acid receptor responder 1), RARRES2 (retinoic acid receptor responder 2), RBP1 (retinol-binding protein 1), SAT (spermidine/ spermine
N1-acetyltransferase), and TXN (thioredoxin), while 6 were down-regulated: ALOX5AP (arachidonate 5-lipoxygenase-activating protein), CLNS1A (chloride channel nucleotide-sensitive 1A), EIF4A2 (eukaryotic translation initiation factor 4A2), ELK3 (ETS-domain protein, SRF accessory protein 2), DF2/REQ (apoptosis response zinc finger gene), and SYPL (synaptophysin-like protein).
The polyamines putrescine (PU), spermidine (SMD), and spermine
(SM) are some of the major cations in eukaryotic cells.